Mitochondrial Signaling In Health And Disease by Sten OrreniusMitochondrial Signaling In Health And Disease by Sten Orrenius

Mitochondrial Signaling In Health And Disease

EditorSten Orrenius, Lester Packer, Enrique Cadenas

Hardcover | June 20, 2012

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Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease.Mitochondrial Signaling in Health and Diseaseexamines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.

With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include:

  • Electron transport and energy production
  • Mitochondrial biogenesis and dynamics
  • Mitochondrial signaling
  • Apoptosis and autophagy
  • Pharmacology signaling
  • Epigenetic signaling: mitochondrial methylation and acetylation reactions

An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.


Sten Orrenius,M.D., Ph.D., holds honorary memberships in the American Society for Pharmacology and Experimental Therapeutics, the American Society for Biochemistry and Molecular Biology, the Society of Toxicology (USA), as well as the Italian and Swedish Societies of Toxicology. He is also a Member of the Royal Swedish Academy of Scien...
Title:Mitochondrial Signaling In Health And DiseaseFormat:HardcoverDimensions:530 pages, 9.25 × 6.14 × 0.98 inPublished:June 20, 2012Publisher:Taylor and FrancisLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1439880026

ISBN - 13:9781439880029

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Table of Contents

Mitochondria¿Reactive Oxygen Species (ROS)¿Cell Death
A Healthy Free Radical Pessimism: A Glance from an Oxidative Lipidomics Corner;V. E. Kagan, A. A. Shvedova, and Y. Y. Tyurina
Mitochondrial Involvement in the Execution of Cell Death;V. Gogvadze, B. Zhivotovsky, and S. Orrenius
The Role of Protein Kinase C in Mitochondrial Functions in Cardiac Ischemia- Reperfusion Injury;J. C. B. Ferreira and D. Mochly-Rosen
Mitocans, Mitochondria-Targeting Anticancer Drugs: Focus on Mitochondrial Complexes;J. Neuzil, L.-F. Dong, and J. Rohlena
Therapeutic Potential of Lipoamide and Enhanced Mitochondrial Biogenesis for Treatment of Insulin Resistance;W. Shen, D. A. Carlson, L. Packer, E. Cadenas, and J. Liu
Mitochondria-Targeted Antioxidants;R. A. J. Smith, R. C. Hartley, and M. P. Murphy

Mitochondria¿Metabolism¿Nitric Oxide
Lactate Shuttling and the Mitochondrial Lactate Oxidation Complex;G. A. Brooks
Nitric Oxide in the Regulation of Mitochondrial Biogenesis;C. De Palma and E. Clementi
Effect of Sildenafil on Heart Nitric Oxide Metabolism and Mitochondrial Function;T. Zaobornyj, L. B. Valdez, and A. Boveris
Kinases and Mitochondrial Cycling: The Last Encounter; M. C. Carreras and J. J. Poderoso

Nuclear Chromatin Factors Defining Mitochondrial Bioenergetics: Implications in Age-Associated Diseases;P. Puigserver and L. Guarente
Mitochondrial Protein Acetylation and Sirtuin-Mediated Deacetylation;L. Valente, R. Szklarczyk, M. A. Huynen, and J. N. Spelbrink
Mitochondrial Regulation by Protein Acetylation;D. B. Lombard, D. X. Tishkoff, and B. M. M.
Calorie Restriction, Mitochondria, and Longevity inSaccharomyces cerevisiae;C. Skinner and S.-J. Lin
Autophagy and Aging: Keeping Organelles and the Proteome Healthy;J. L. Schneider and A. M. Cuervo

Mitochondrial Dynamics and Its Implications in Metabolic Dysregulation and Neurodegeneration;A. Zorzano, J. Segal¿ M. I. Hern¿ez-Alvarez, and E. Sorianello
Mitochondrial Abnormalities and Oxidative Stress in Alzheimer¿s Disease: Can Mitochondrial Reactive Oxygen Species Signaling Promote Neuronal Survival?P. I. Moreira and C. R. Oliveira
The Role of Mitochondria in Parkinson¿s Disease and Huntington¿s Disease;A. H. V. Schapira
¿-Ketoglutarate Dehydrogenase Complex in Neurodegeneration;G. E. Gibson, A. Starkov, Q. Shi, and M. Flint Beal
-¿-Lipoic Acid as a Potent Agent of Mitochondrial Protection in Alzheimer¿s Disease;D. J. Bonda, M. A. Smith, G. Perry, H.-g. Lee, X. Wang, and X. Zhu
Mitochondrial Antioxidants in Neuroprotection;G. Fiskum and M. D. Laird