Modeling and Analysis of Signal Transduction Networks by Juergen HahnModeling and Analysis of Signal Transduction Networks by Juergen Hahn

Modeling and Analysis of Signal Transduction Networks

Guest editorJuergen Hahn

Hardcover | April 29, 2016

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Biological pathways, such as signaling networks, are a key component of biological systems
of each living cell. In fact, malfunctions of signaling pathways are linked to a number of
diseases, and components of signaling pathways are used as potential drug targets. Elucidating
the dynamic behavior of the components of pathways, and their interactions, is one of the key
research areas of systems biology.
Biological signaling networks are characterized by a large number of components and an
even larger number of parameters describing the network. Furthermore, investigations of
signaling networks are characterized by large uncertainties of the network as well as limited
availability of data due to expensive and time-consuming experiments. As such, techniques
derived from systems analysis, e.g., sensitivity analysis, experimental design, and parameter
estimation, are important tools for elucidating the mechanisms involved in signaling networks.
This Special Issue contains papers that investigate a variety of different signaling networks via
established, as well as newly developed modeling and analysis techniques.

Title:Modeling and Analysis of Signal Transduction NetworksFormat:HardcoverProduct dimensions:232 pages, 9.61 × 6.69 × 0.75 inShipping dimensions:9.61 × 6.69 × 0.75 inPublished:April 29, 2016Publisher:MDPI AGLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3038421413

ISBN - 13:9783038421412


Table of Contents

Preface: Modeling and Analysis of Signal Transduction NetworksPredicts the Network Balances and Timing Constraints Critical to the Hepatic Stellate CellActivation ProcessMathematical Modeling and Analysis of Crosstalk between MAPK Pathway andSmad-Dependent TGF-? Signal TransductionResolving Early Signaling Events in T-Cell Activation Leading to IL-2 and FOXP3TranscriptionbyMathematical Modeling of Pro- and Anti-Inflammatory Signaling in MacrophagesModeling the Dynamics of Acute Phase Protein Expression in Human Hepatoma CellsStimulated by IL-6A Computational Study of the Effects of Syk Activity on B Cell Receptor SignalingDynamicsDynamic Modeling of the Human Coagulation Cascade Using Reduced Order EffectiveKinetic ModelsA Quantitative Systems Pharmacology Perspective on Cancer ImmunologyNetwork Analysis Identifies Crosstalk Interactions Governing TGF-? Signaling Dynamicsduring Endoderm Differentiation of Human Embryonic Stem Cells