Models of Cellular Regulation

Paperback | August 23, 2012

byBaltazar Aguda, Avner Friedman

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The human genome of three billion letters has been sequenced. So have the genomes of thousands of other organisms. With unprecedented resolution, modern technologies are allowing us to peek into the world of genes, biomolecules, and cells - and flooding us with data of immense complexity thatwe are just barely beginning to understand. A huge gap separates our knowledge of the components of a cell and what is known from our observations of its physiology. The authors have written this graduate textbook to explore what has been done to close this gap of understanding between the realms of molecules and biological processes. They have gathered together illustrative mechanisms and models of gene regulatory networks, DNA replication, the cell cycle, celldeath, differentiation, cell senescence, and the abnormal state of cancer cells. The mechanisms are biomolecular in detail, and the models are mathematical in nature. The interdisciplinary presentation will be of interest to both biologists and mathematicians, and every discipline in between.

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The human genome of three billion letters has been sequenced. So have the genomes of thousands of other organisms. With unprecedented resolution, modern technologies are allowing us to peek into the world of genes, biomolecules, and cells - and flooding us with data of immense complexity thatwe are just barely beginning to understand. ...

Baltazar Aguda is Visiting Associate Professor at The Ohio State University. Avner Friedman is Director of the Mathematical Biosciences Institute at The Ohio State University.
Format:PaperbackDimensions:200 pages, 9.69 × 6.73 × 0.01 inPublished:August 23, 2012Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199657505

ISBN - 13:9780199657506

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Table of Contents

1. General Introduction2. From Molecules to a Living Cell3. Mathematical and Computational Modeling Tools4. Gene regulatory networks: from DNA to metabolites and back5. Control of DNA replication in a prokaryote6. The Eukaryotic Cell Cycle Engine7. Cell Cycle Control8. Cell Death9. Cell Differentiation10. Cell Aging and Renewal11. Multiscale Modeling of Cancer