Modern Molecular Biology:: Approaches for Unbiased Discovery in Cancer Research

Hardcover | September 8, 2010

EditorSrinivasan Yegnasubramanian

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Molecular biology has rapidly advanced since the discovery of the basic flow of information in life, from DNA to RNA to proteins. While there are several important and interesting exceptions to this general flow of information, the importance of these biological macromolecules in dictating the phenotypic nature of living creatures in health and disease is paramount. In the last one and a half decades, and particularly after the completion of the Human Genome Project, there has been an explosion of technologies that allow the broad characterization of these macromolecules in physiology, and the perturbations to these macromolecules that occur in diseases such as cancer. In this volume, we will explore the modern approaches used to characterize these macromolecules in an unbiased, systematic way. Such technologies are rapidly advancing our knowledge of the coordinated and complicated changes that occur during carcinogenesis, and are providing vital information that, when correctly interpreted by biostatistical/bioinformatics analyses, can be exploited for the prevention, diagnosis, and treatment of human cancers.The purpose of this volume is to provide an overview of modern molecular biological approaches to unbiased discovery in cancer research. Advances in molecular biology allowing unbiased analysis of changes in cancer initiation and progression will be overviewed. These include the strategies employed in modern genomics, gene expression analysis, and proteomics.

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Molecular biology has rapidly advanced since the discovery of the basic flow of information in life, from DNA to RNA to proteins. While there are several important and interesting exceptions to this general flow of information, the importance of these biological macromolecules in dictating the phenotypic nature of living creatures in h...

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A convergence of advancements in molecular biology, engineering, computer science, biostatistics and other disciplines has made possible the development of technologies facilitating the massively parallel investigation of the complex biological phenomena driving cancer initiation and progression. Such technologies include DNA microarra...

Format:HardcoverDimensions:204 pages, 9.25 × 6.1 × 0.39 inPublished:September 8, 2010Publisher:SpringerLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0387697446

ISBN - 13:9780387697444

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Table of Contents

Chapter 1: Genome-scale analysis of data from high-throughput technologiesby Sarah J. WheelanChapter 2: Analysis of Inherited and Acquired Genetic Variationby Srinivasan Yegnasubramanian and William B. IsaacsChapter 3: Examining DNA-Protein Interactions with genome-wide chromatin immunoprecipitation (ChIP) analysisby Esteban Ballestar and Manel EstellerChapter 4: Genome-wide DNA methylation analysis in cancer researchby Srinivasan Yegnasubramanian and William G. NelsonChapter 5: Use of expression microarrays in cancer researchby Jun Luo and Yidong ChenChapter 6: Signal sequencing for gene expression profilingby Biaoyang Lin, Jeremy Wechsler, Leroy HoodChapter 7: Mass spectrometry based proteomics in cancer researchby Mohamad Abbani, Parag Mallick, Maryann VogelsangChapter 8: Tissue microarrays in cancer researchby Toby Cornish and Angelo De Marzo