Modifications of Nuclear DNA and its Regulatory Proteins

Other | June 1, 2011

byCheng, Xiaodong, Xiaodong Cheng

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DNA methylation is essential for the normal development and functioning of organisms. This volume discusses the latest developments in this very active field of research. It presents the evolution of DNA methylation, mammalian DNA methyltransferases, DNA methylation and demethlyation, DNA methylation and silencing and the role it plays in medicine including cancer.



* Discusses new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

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DNA methylation is essential for the normal development and functioning of organisms. This volume discusses the latest developments in this very active field of research. It presents the evolution of DNA methylation, mammalian DNA methyltransferases, DNA methylation and demethlyation, DNA methylation and silencing and the role it plays...

Format:OtherDimensions:502 pages, 1 × 1 × 1 inPublished:June 1, 2011Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123876869

ISBN - 13:9780123876867

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Table of Contents

  1. Introduction - Epiphanies in Epigenetics Xiaodong Chengand Robert M. Blumenthal
  2. Section I. EVOLUTION OF DNA METHYLATION

  3. The natural history of eukaryotic DNA methylation systems Lakshminarayan M. Iyer, Saraswathi Abhiman, L. Aravind
  4. Evolution of histone methyltransferases and demethylases L. Aravind
  5. DNA methylation in Drosophila - A critical evaluation Veiko Krauss and Gunter Reuter
  6. DNA Methylation in Zebrafish Mary G Golland Marnie E Halpern
  7. Seciton II. MAMMALIAN DNA METHYLTRANSFERASES - STRUCTURE AND FUNCTION

  8. Dnmt1 - structure and function Željko M. SvedružiÄ
  9. The DNMT3 family of MAMMALIAN de novo DNA methyltransferases Frédéric Chédin
  10. Seciton III. DNA METHYLATION AND DEMETHYLATION

  11. Recruitment of Dnmt1: Roles of the SRA protein Np95 (Uhrf1) and other factors Jafar Sharif & Haruhiko Koseki
  12. Regulation of Expression and Activity of DNA (cytosine-5) methyltransferases in mammalian cells Shannon R. Morey Kinney and Sriharsa Pradhan
  13. Mechanistic and functional links between histone methylation and DNA methylation Taiping Chen
  14. Section IV. DNA METHYLATION IN MEDICINE

  15. RNA mediated silencing mechanisms in mammalian cells Anton Wutz
  16. Biological functions of methyl-CpG binding proteins Pierre-Antoine Defossez and Irina Stancheva
  17. Section V. DNA METHYLATION IN MEDICINE

  18. Diseases associated with imprinting J.F. Wilkins and F. Úbeda
  19. DNA methylation changes in cancer Minoru Toyota and Eiichiro Yamamoto
  20. Epigenetic biomarkers J. Tost
  21. Distribution of methylation at the single-nucleotide level E. Wong