Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes: Proceedings of a NATO ASI…

Hardcover | January 31, 1999

EditorEmel Arinç, John B. Schenkman, Ernest Hodgson

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Written by leading researchers in the fields of biochemistry, molecular biology, genetics, pharmacology, toxicology, biotechnology and cancer, this is a comprehensive update on molecular biology and biochemistry of cytochromes P450 and flavin containing monoxygenases. The volume provides expert analysis of the genetic polymorphism of these enzymes in the clinic, in drug discovery and development, and discussion of their role in predisposition for, and prevention of chemical carcinogens in humans.

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Written by leading researchers in the fields of biochemistry, molecular biology, genetics, pharmacology, toxicology, biotechnology and cancer, this is a comprehensive update on molecular biology and biochemistry of cytochromes P450 and flavin containing monoxygenases. The volume provides expert analysis of the genetic polymorphism ...

Format:HardcoverDimensions:302 pages, 10 × 7.01 × 0.27 inPublished:January 31, 1999Publisher:Springer USLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0306460483

ISBN - 13:9780306460487

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Table of Contents

The Fate of Xenobiotics in the Body; Enzymes of Metabolism; J.B. Schenkman. Protein-Protein Interactions in the P450 Monooxygenase System; J.B. Schenkman, et al. Structures of Mitochondrial P450 System Proteins; I. Hanukoglu. Biochemical Aspects of Flavin-Containing Monooxygenases (FMOs); E. Hodgson, et al. Expression and Regulation of Flavin-Containing Monooxygenases; R.M. Philpot, et al. Correlations between in Vivo and in Vitro Studies in Human Drug Metabolism; M. Eichelbaum. Pharmacogenetics: Polymorphisms in Xenobiotic Metabolism; F.J. Gonzalez. Clinical Aspects of Polymorphic Drug Metabolism in Humans; M. Eichelbaum. Genetic Polymorphisms of Cytochromes P450 1A1 and 2E1 and Glutathione S-Transferase M1 and Cancer Susceptibility in the Human; M. Watanabe. Cytochrome P450 Isoforms: Insecticide Metabolism in Insects and Mammals and Role in Insecticide Resistance; E. Hodgson, et al. Inhibitors of CYP51 as Antifungal Agents and Resistance to Azole Antifungals; S.L. Kelly, et al. The Role of Oxidative Drug Metabolizing Enzymes in Liver and Lung Specific Toxicity; R.M. Philpot. Importance of Drug Metabolism in Drug Discovery and Development; R. Gasser. 7 additonal articles. Index.