Molecular And Cell Biology Of Autoantibodies And Autoimmunity. Abstracts: First International Workshop July 27-29, 1989, Heidelberg by Ekkehard K.F. BautzMolecular And Cell Biology Of Autoantibodies And Autoimmunity. Abstracts: First International Workshop July 27-29, 1989, Heidelberg by Ekkehard K.F. Bautz

Molecular And Cell Biology Of Autoantibodies And Autoimmunity. Abstracts: First International…

EditorEkkehard K.F. Bautz, Joachim R. Kalden, Mitsuo Homma

Paperback | July 25, 1989

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The 1st International Workshop in the Molecular and Cell Biology of Autoan­ tibodies and Autoimmunity is convened at a time when recombinant DNA tech­ niques have yielded the first set of data providing initial glimpses of epitopes recognized by autoantibodies. It's aim is to bring together cell and molecular biologists with clinical scien­ tists to discuss the broad spectrum of questions concerning the relationship be­ tween clinical symptoms and the specificity of autoantibodies. The response to the call for abstracts was overwhelming: Nearly one hundred abstracts were received from many laboratories throughout the world. The topics covered by them are representative of the current research efforts going on to study cause and effect of autoimmune diseases. One of the aims of this workshop is to bring the rapid advances in the elucidation of the molecular structure of auto antigens to the attention of immunologists, cell biologists and clinical scien­ tists and also to make molecular biologists bei6ple aware of the difficulties lying ahead in trying to understand the cellular and molecular basis of rheumatic dis­ eases. The organisers wish to thank NIH, BMFT and the Japanese Educational Foundation for financial support, the Heidelberg Academy for the Humanities and Sciences for hosting the workshop, Springer Verlag for their generous cooperation in including late abstracts in this volume, and, last not least, Ms. Simone KRAMBS for untiring secretarial help.
Title:Molecular And Cell Biology Of Autoantibodies And Autoimmunity. Abstracts: First International…Format:PaperbackPublished:July 25, 1989Publisher:Springer Berlin HeidelbergLanguage:English

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ISBN - 10:3540514368

ISBN - 13:9783540514367

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Table of Contents

Clinical and Etiopathogenetic Significances of Autoantibodies to the Cellular Antigens in Systemic Connective Tissue Diseases.- Cloning of a cDNA-Fragment Coding for an Epitope Recognized by Anti-PM/Scl-Autoantibodies.- Fibrillarin from Xenopus laevis: cDNA Cloning and Expression During Development.- Nuclear Receptors as Transcriptional Enhancers.- Multiple Components of SS-A/Ro Autoantigen: cDNA Cloning of the 52 kDa Protein.- Autoantibodies to Nuclear Envelope Proteins: Characterization and Clinical Significance.- Cloned Human snRNP Proteins B and B? Differ Only in Their Carboxy-Terminal Part.- Antibodies to Ribonucleoprotein (RNP) from Autoimmune Sera Detected by Immunoblot on Tissue Extracts.- Analysis of the 60 kD Ro Protein - hY RNA Complex: An RNA Recognition Motif Within Ro Protein is Required for Binding to hY 1 RNA.- Monoclonal Autoantibodies Against Nuclear Proteins.- Alterations of the Macrophage System in Systemic Lupus Erythematosus (SLE) Developing NZB/W Mice.- Cytoskeletal Proteins: Major Antigens in Autoimmune Diseases.- Leucine Periodicity of U2 snRNP Autoantigen A? Implicated in U2 snRNP Protein: Protein Interactions.- Epitope Mapping of the Recombinant Human U1 snRNP 68 k Protein.- Molecular Characterization of the PM/SCL Antigen.- Chronic Graft-versus-Host Disease. A Model for the Study of the Autoimmune Phenomenon.- Immunogenetic Studies in Patients with Scleroderma-Associated Autoantibodies.- The TH Ribonucleoprotein Particle: Identity with RNase MRP and Association with RNase P.- Immunoregulatory Effects of Borrelia Burgdorferi Antigens in Patients with Chronic Lyme Disease.- Molecular Mimicry: A Common Epitope of the (U 1) snRNP Associated p68 Autoantigen and a Protein of a Human Pathogenic Virus.- Human Autoantibodies to Synaptonemal Complex.- Immunolocalization and Number of Transcriptionally Active rRNA Genes in Vertebrate Cells.- Mapping of Autoimmune Reactive Sites on snRNP Proteins.- Clinical Significances of Rare Autoantibodies to Small Nuclear and Cytoplasmic Ribonucleoproteins.- Molecular Cloning and Expression of cDNAs Encoding snRNP Polypeptide Autoantigens.- U 1-68 Kd Protein-Positive Mixed Connective Tissue Disease is Associated with HLA-DR4 and Appears Genetically Distinct from Systemic Lupus Erythematosus.- A Novel Trait of Naturally-Occurring Anti-DNA Antibodies: Dissociation from Immune Complexes in Neutral 0.3-0.5 M NaC1.- Immunoblotting Analysis in Antigenic Components of Circulating Immune Complexes of Rheumatoid Arthritis and Systemic: Lupus Erythematosus Patients.- The Human La Autoantigen Contains an RNA Binding Domain and an ATP Binding Domain.- Autoantibodies to "HSP 70 Class" Proteins in Sera of Systemic Lupus Erythematosus (SLE) Patients and Healthy Subjects. A Spontaneous Expression of HSP 70 Autoantibodies.- Cross-Reactive Rheumatoid Factor in Rheumatoid Arthritis with Extra-Articular Disease.- Profiles of Anti-Nuclear Antibodies in Scleroderma Spectrum Disorders.- Desmin Antibodies in Acute Myopericarditis.- Ankylosing Spondylitis (AS) and Rheumatoid Arthritis (RA): Improved Diagnosis and Attempts Towards the Molecular Analysis of Etiology and Pathogenesis of These Systemic Rheumatic Diseases.- Characterization of the snRNP Protein N: Description of a Potential Sm Epitope.- Antigenic Structure of U snRNPs and Experimental Induction of Anti-U snRNP Autoantibodies in Mice.- The U 1 RNA Binding Site of the U 1 snRNP-Associated A Protein Overlaps an Anti-U1 RNA Antibody Binding Site.- Anti-Ribosomal P Protein Antigens and Antibodies.- Molecular Identification of the M2 Antigens of Primary Biliary Cirrhosis.- Molecular Biological Identification of Autoantigens in Autoimmune Hepatitis - Relevance for Pathogenesis, Diagnosis, and Treatment.- Aminoacyl-tRNA Synthetases: an Overview.- A New Autoantibody Specific for the Limited Systemic Sclerosis (lSSc) Found Through Molecular Biology.- Determination of an Epitope of the Diffuse Scleroderma Marker Antigen Topoisomerase I. Sequence Similarity with Retroviral p 30gag Protein Suggests a Possible Cause for Autoimmunity in Scleroderma.- The Spectrum of Antinuclear Antibodies (ANA) and Clinical Findings in Children with Anti-U 1-RNP Antibodies.- Molecular Cloning of the Human Autoantigen KU (p 70/p 80), a DNA-Terminal-Binding Protein Complex.- Autoantibodies to a Histone Cross-Reactive DNA-Binding Protein of Mr 110000 in Systemic Lupus Erythematosus and Other Diseases and in Autoimmune Mice.- cDNA Cloning and Expression of U1snRNP C Protein.- Further Characterization of the Anti-Wa Antibody to a tRNA-Related Protein in Progressive Systemic Sclerosis.- Characteristics and Interrelation of Autoantibodies in Scleroderma Sera.- Characterization of an Autoantigen in Graves' Hyperthyroidism.- Clinical Significance of Anti-Ubiquitin Antibodies in Systemic Lupus Erythematosus.- The Natural History of PCNA/Cyclin.- Identification of Several Independent Autoreactive Epitopes of the Human 68 kDa (U 1) snRNP-Autoantigen.- Current Ideas on Tolerance Mechanisms and Autoimmunity.- Molecular Cloning of a cDNA for the B-Polypeptide of the U snRNPs.- The Induction of Anti-DNA Antibodies in Normal Mice by Immunization with Bacterial DNA.- The Binding of Anti-La Antibodies to Fusion Proteins Containing Various La Epitopes.- Isolation and Sequencing of Human Lamin ? cDNA: Mammalian Lamins A, B and C Contain Leucine Heptad Repeats.- Detection of Autoantibodies Using Recombinant Antigens.- A Common RNA Recognition Motif Identified Within a Defined U 1 RNA-Binding Domain of the 70K U1 snRNP Autoantigen.- Characterization of Nucleolar 7-2 RNP Recognized by Sera from Patients with Autoimmune Diseases.- Structure and Antigenicity of the p70 (Ku) Autoantigen.- Synthetic Peptides as Probes for Autoantibodies.- cDNA Sequencing and Expression of B/B?-Proteins of RNP Autoantigens in E. coli.- Compartmentalization of Nuclear Antigens Detected by Autoantibodies.- Anti-A. R.: A New Autoantibody/ies in Autoimmune Chronic Active Hepatitis (CAH) that Precipitates a 4.5 S RNA.- Immunological Crossreactivity Between RNA Polymerase I and the Glycine Rich Repeats of Epstein-Barr Virus Nuclear Antigen.- Drug Induced Anti-Histone Antibodies Reflect Nucleosomal Substructures.- Epitope Mapping of the Ro-RNP Autoantigen Using Recombinant Polypeptides.- Idiotype Network and Anti-DNA Antibody Production.- In Vitro Binding of A and B? snRNP Proteins to U1 and U2 snRNAs.- Expression of the 70 kD RNP Autoantigen in E. coli and Its Use in ELISA-Screening of Patients Sera.- The Autoantibody Expression in Cultured Cell Lines of Human Keratinocytes Transformed by Virus and by Ultraviolet Light in SLE and Other Autoimmune Diseases.- The B Cell Activation in Autoimmunity.- Rheumatoid Factor Idiotypes in Lymphoproliferative Disorders in Patients with Sjörgren's Syndrome.- Snurps and Scyrps - Insights into the Biology of RNA Processing.- Genetic Restriction of Autoantibody Production in Patients with Systemic Lupus Erythematosus.- Localization of an Immunopathologically Important Epitope in the Bovine Retinal S-Antigen by the Pepscan Method.- Anti-Peptide Antibodies to Three CDR Sequences of Human Monoclonal Anti-DNA Autoantibodies.- Immunological Characterization of IgM Class Autoantibodies Against Sm-Antigenic B?/B and D Polypeptides of U Small Nuclear Ribonucleoproteins (snRNPs).- Enzyme-Linked Immunosorbent Assay Using Isolated (U) Small Nuclear Ribonucleoprotein Polypeptides as Antigens.- Analysis of U1 Ribonucleoprotein (RNP) 68K Polypeptide (p 68K) Epitopes by Enzyme-Linked Immunosorbent Assay (ELISA) with Fusion Proteins (FPs).- Contributions of Molecular and Cell Biology to Understanding of the B-Cell Response in Systemic Autoimmunity.- Immunospecificity and Clinical Association of Autoantibodies in Sera Precipitating U1 and U2 Small Nuclear RNAs.- Anti-JO-1 Antibodies are Directed at an Evolutionarily-Conserved, Conformational Site on Human Histidyl-tRNA Synthetase.- Molecular Considerations of Primary Biliary Cirrhosis: Definition of Dihydrolipoamide Acetyltransferase and Identification of Immunoreactive Sites.- Association of Seropositive Rheumatoid Arthritis (RA) with the Third Hypervariable Region (HVR3) of the HLA-DR ?1-Chain: Functional Implications for Antigen-Specific and Allogeneic T Cell Recognition.- The snRNP E Protein: Structure and Expression of a Human Autoimmune Antigen.- Autoantibodies to Nonhistone Chromosomal Proteins HMG-1 and HMG-2 in Subsets of Juvenile Chronic Arthritis (JCA).- A Human T Cell Clone Recognizing Small Nuclear Ribonucleoproteins (UsnRNP).- Epitope Progression in Autoantibody Production Suggested by Epitope Mappings of SS-B/La and U2snRNP B? Protein.- Association of Autoantigenic Epitope and Catalytic Site on Poly (ADP-Ribose) Polymerase.- Rheumatoid Arthritis is Associated with the Presence of Anti-Nuclear Antibodies to a 33kD Protein (RA 33) and Related Antigens.- Molecular Cloning and Identification of Retroviral Nucleic Acids Associated with Systemic Lupus Erythematosus.- Molecular Features of an RNA Recognition Motif Family of Proteins.- Detection of HIV-Homologous DNA and RNA in Systemic Lupus Erythematosus.- Heterogeneity of the Ro(SSA) Antigen and the Autoanti-Ro(SSA) Response: Evidence for 4 Antigenically Distinct Forms.- Molecular Cloning of Ki Antigen C DNA and Enzyme-Linked-Immunosorbent-Assay for Anti-Ki Using Recombinant Ki.- Antibodies to Nuclear Lamin C in Chronic Hepatitis Delta Virus Infection.