Molecular and Cell Biology of Neuropsychiatric Diseases by F. OwenMolecular and Cell Biology of Neuropsychiatric Diseases by F. Owen

Molecular and Cell Biology of Neuropsychiatric Diseases

byF. OwenEditorR. Itzhaki

Paperback | October 28, 2012

Pricing and Purchase Info

$175.54 online 
$191.95 list price save 8%
Earn 878 plum® points

Prices and offers may vary in store

Quantity:

In stock online

Ships free on orders over $25

Not available in stores

about

is'0l m 5-HT Ante-mortem (m = metabolite) . ". <_20_.20_27_27_-27_27_-27_27_-27_27_-27_27_-20_.20_22_20_somatostatin20_.20_27_27_120_plaques20_tangles20_2a_20_.20_22_.20_.20_22_.20_.20_27_27_i20_synapse20_loss20_2a_20_chat20_22_20_ach20_synthesis20_l22_-2c_.20_27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-20_2c_2c_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-20_2a_20_neuronal20_loss20_2c_2c_-20_2c_2c_-20_.20_22_.20_2a_20_o20_0.20_120_0.20_220_0.20_320_0.20_420_0.20_520_0.20_620_0.20_720_0.20_820_0.20_920_1.20_020_correlation20_coefficient20_with20_dementia20_rating20_figure20_2.20_120_various20_neurotransmitter20_and20_neuropathological20_measures20_on20_neocortex20_obtained20_either20_at20_diagnostic20_craniotomy20_28_ante-mortem29_20_or20_post-mortem20_and20_rec2ad_20_lationship20_to20_cognitive20_impairment20_28_dementia20_rating29_.20_asterisks20_identify20_significant20_correlations.20_negative20_and20_positive20_correlations20_are20_not20_identified20_in20_this20_represenc2ad_20_tation20_of20_the20_data.20_only20_the20_physiologically20_relevant20_measure20_of20_cholinergic20_neurones20_28_acetylcholine20_synthesis29_20_and20_indices20_of20_cortical20_pyramidal20_neurone20_degeneration20_28_neuronal20_loss2c_20_synapse20_loss20_and20_tangles29_20_correlate20_with20_severity20_of20_dementia.20_note20_the20_lack20_of20_correlation20_with20_the20_structural20_marker20_of20_cholinergic20_neurones2c_20_chat20_activity.20_loss20_of20_enzyme20_exceeded20_that20_of20_acetylcholine20_synthesis20_28_sims20_et20_al.20_2c_20_1983a29_2c_20_suggesting20_a20_compensatory20_increase20_in20_synthesis20_in20_the20_few20_remaining20_neurones.20_data20_derived20_from20_palmer20_28_198729_20_and20_terry20_et20_al.20_28_199129_.20_emission20_tomography20_28_pet29_20_and20_magnetic20_resonance2c_20_may20_some20_day20_proc2ad_20_vide20_routine20_insight20_into20_differences20_in20_brain20_functioning.20_success20_in20_developing20_rapid20_and20_reliable20_diagnostic20_procedures2c_20_perhaps20_based20_on20_changes20_in20_body20_fluid20_that20_reflect20_specific20_alterations20_in20_brain20_protein20_metabolism2c_20_should20_ultimately20_play20_an20_important20_role20_in20_the20_clinical20_development20_of20_new20_therapeutic20_agents. .="" _27_27_-27_27_-27_27_-27_27_-27_27_-="" _22_="" somatostatin="" _27_27_1="" plaques="" tangles="" _2a_="" _22_.="" _27_27_i="" synapse="" loss="" chat="" ach="" synthesis="" _l22_-2c_.="" _27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-="" _2c_2c_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-27_27_-="" neuronal="" _2c_2c_-="" o="" 0.="" 1="" 2="" 3="" 4="" 5="" 6="" 7="" 8="" 9="" 1.="" 0="" correlation="" coefficient="" with="" dementia="" rating="" figure="" 2.="" various="" neurotransmitter="" and="" neuropathological="" measures="" on="" neocortex="" obtained="" either="" at="" diagnostic="" craniotomy="" _28_ante-mortem29_="" or="" post-mortem="" _rec2ad_="" lationship="" to="" cognitive="" impairment="" _28_dementia="" _rating29_.="" asterisks="" identify="" significant="" correlations.="" negative="" positive="" correlations="" are="" not="" identified="" in="" this="" _represenc2ad_="" tation="" of="" the="" data.="" only="" physiologically="" relevant="" measure="" cholinergic="" neurones="" _28_acetylcholine="" _synthesis29_="" indices="" cortical="" pyramidal="" neurone="" degeneration="" _28_neuronal="" _loss2c_="" _tangles29_="" correlate="" severity="" dementia.="" note="" lack="" structural="" marker="" _neurones2c_="" activity.="" enzyme="" exceeded="" that="" acetylcholine="" _28_sims="" et="" al.="" _2c_="" _1983a29_2c_="" suggesting="" a="" compensatory="" increase="" few="" remaining="" neurones.="" data="" derived="" from="" palmer="" _28_198729_="" terry="" _28_199129_.="" emission="" tomography="" _28_pet29_="" magnetic="" _resonance2c_="" may="" some="" day="" _proc2ad_="" vide="" routine="" insight="" into="" differences="" brain="" functioning.="" success="" developing="" rapid="" reliable="" _procedures2c_="" perhaps="" based="" changes="" body="" fluid="" reflect="" specific="" alterations="" protein="" _metabolism2c_="" should="" ultimately="" play="" an="" important="" role="" clinical="" development="" new="" therapeutic="">
Title:Molecular and Cell Biology of Neuropsychiatric DiseasesFormat:PaperbackDimensions:201 pages, 23.5 × 15.5 × 0.01 inPublished:October 28, 2012Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9401043051

ISBN - 13:9789401043052

Look for similar items by category:

Reviews

Table of Contents

Molecular biology of Huntington's disease. Neuronal pathology in relation to molecular biology and treatment of Alzheimer's disease. The aetiology of Alzheimer's disease. The molecular genetics of Alzheimer's disease. The molecular biology of the transmissible dementias. The neurochemistry of schizophrenia. Molecular biology of shcizophrenia. Genetics and molecular biology of manic-depression. Index.