Molecular And Cellular Therapies For Motor Neuron Diseases

Hardcover | January 1, 2017

byNicholas M BoulisEditorDeirdre O Connor, Anthony Donsante

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Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis ALS/Lou Gehrig's Disease and Spinal Muscular Atrophy SMA , along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials. Provides an overview of gene and cell therapies for amyotrophic lateral sclerosis ALS and other motor neuron diseases Edited by a leading Neurosurgeon and two research scientists to promote synthesis between basic neuroscience and clinical relevance Presents a great resource for researchers and practitioners in neuroscience, neurology, and gene and cell therapy

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From the Publisher

Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive over...

From the Jacket

Motor Neuron Diseases (MND) are a group of neurological disorders that affect motor neurons in adults and in children. The fields of gene and cell therapies for motor neuron diseases are constantly evolving.Molecular and Cellular Therapies for Motor Neuron Diseasediscusses the basics of the diseases and covers both advances in research...

Dr. Nicholas Boulis is a physician scientist whose research interests include biological neurorestoration and neuromodulation through the use of cell, protein and gene delivery to the nervous system. Dr. Boulis graduated Summa Cum Laude from Yale University with distinction in intensive Biology and Philosophy majors and graduated Magna...
Format:HardcoverDimensions:350 pages, 9.41 × 7.24 × 0.98 inPublished:January 1, 2017Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128022574

ISBN - 13:9780128022573

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Table of Contents

1. Molecular and Extracellular Cues in Motor Neuron Specification and Differentiation
Raymond L. Swetenburg, Steve L. Stice and Lohitash Karumbaiah
2. Natural History of ALS
Marcus J. Magnussen and Jonathan D. Glass
3. Genetics of ALS
Kevin P. Kenna, John E. Landers and Nicola Ticozzi
4. Molecular Mechanisms of Amyotrophic Lateral Sclerosis
Mahlon Collins and Robert Bowser
5. An Introduction to the Natural History, Genetic Mapping, and Clinical Spectrum of Spinal Muscular Atrophy
Annie McDonough, Lyndsey Urquia and Nicholas M. Boulis
6. Genetics of Spinal Muscular Atrophy
Arthur H.M. Burghes and Vicki L. McGovern
7. Introduction to Gene and Stem Cell Therapy
Deirdre O'Connor
8. Gene Therapy for ALS 1: Therapeutic Transgenes
Anthony Donsante
9. Stem Cell Therapy for ALS
Kevin S. Chen and Eva L. Feldman
10. Gene Therapy for Spinal Muscular Atrophy
Madeline R. Miller, Erkan Y. Osman and Christian L. Lorson
11. Cellular Therapy for Spinal Muscular Atrophy: Pearls and Pitfalls
Irene Faravelli and Stefania Corti
12. Clinical Trials to Date
Burton J. Mader and Nicholas M. Boulis