Molecular Basis of Chronic Myeloproliferative Disorders by H.L. PahlMolecular Basis of Chronic Myeloproliferative Disorders by H.L. Pahl

Molecular Basis of Chronic Myeloproliferative Disorders

EditorH.L. Pahl, P.E. Petrides

Paperback | October 8, 2012

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Since the first description of Philadelphia chromosome-negative chronic myeloproliferative disorders more than 100 years ago, the diagnosis and therapy of these conditions have been based primarily on clinical experience and judgement. Until recently very little was known about the molecular basis of these diseases. In order to spark research in this area basic scientists and clinicians from various parts of the world have contributed to this volume, the first of its kind to put together the current knowledge. The book deals with the new WHO classification of these disorders, novel aspects of diagnostic pathology, the search for disease-relevant genes utilizing molecular biology and proteomic techniques, the description of the roles of PVR-1 and VHL genes for polycythemias and the discovery of the gene mutation responsible for the idiopathic hypereosinophilic syndrome. A chapter on anagrelide, an important novel drug for the treatment of primary thrombocythemia, is included.
Title:Molecular Basis of Chronic Myeloproliferative DisordersFormat:PaperbackDimensions:230 pages, 9.25 × 6.1 × 0 inPublished:October 8, 2012Publisher:Springer Berlin HeidelbergLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3642622712

ISBN - 13:9783642622717

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Table of Contents

From the Contents: Basics. Molecular Classification of Chronic Myeloproliferative Disorders.  Cytogenetics.- Polycythemia Vera (PV). Classification and Molecular Biology.  Impaired Expression of the Thrombopoietin Receptor, Mpl, in PV. Growth Factor Signaling in PV Cells. Role of the Antiapoptotic Protein Bcl-xL in the Pathogenesis of PV. Involvement of Chromosome 9 and 11 in Familial and Sporadic PV. - Essential Thrombocythemia (ET).  Regulation of Megakaryocytopoiesis. Hereditary Thrombocythemia. Thromboembolic Complications in ET: The Role of the Analysis of the Platelet Proteome. Clonality Studies in ET. Molecular and Preclinical Aspects of Anagrelide Action.- Chronic Idiopathic Myelofibrosis. Pathophysiology and Stem Cell Biology in Myelofibrosis with Myeloid Metaplasia. Transforming Growth Factor Beta1. Evidence of Crosstalk Between Polymorphonuclear Leukocytes and Megakaryocytes.- Mastocytosis. C-kit and Mastocytosis. Tryptases, a Marker of Occult Mastocytosis.- Hypereosinophilic Syndrome.