Molecular Biology of B Cells

Other | February 19, 2004

byTasuku Honjo, Michael Reth, Michael Neuberger...

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Molecular Biology of B Cellsis a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding of complex phenotyes. The molecular basis of many diseases due to B cell abnormality is also discussed. This definitive reference is directed at research level immunologists, molecular biologists and geneticists.

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Molecular Biology of B Cellsis a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding of complex phenotyes. The molecular basis of many diseases due to B c...

Format:OtherDimensions:600 pages, 1 × 1 × 1 inPublished:February 19, 2004Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080479502

ISBN - 13:9780080479507

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Table of Contents

ORGANIZATION, REARRANGEMENT AND TRANSCRIPTION OF IMMUNOGLOBULIN GENES
Human Immunoglobulin heavy chains locus
Immunoglobulin heavy chain genes of mouse
Immunoglobulin genes of human and mouse
Immunoglobulin lambdav (IGL) genes of human and mouse
The Mechanism of V(D) J Recombination
Transcription of Immunoglobulin genes
B CELLS AND THEIR DEVELOPMENT
Early B cell development to a mature , antigen-sensitive cell - cellular stages and molecular decisions
Allelic exclusion, Isotypic exclusion and the Developmental Regulation of V(D)J Recombination
The Development of Human B Lymphocytes
Development and function of B cell subsets
B CELL DIFFERENTIATION INDUCED BY Ag STIMULATION
Structure and function of B cells antigen receptor complexes
Regulation of antigen receptor signaling by the co-receptors, CD19 and CD22
The dynamic structure of antibody responses
Dynamics of B cell migration to and within secondary lymphoid organs
Characteristics of mucosal B cells with emphasis on the human secretory immune system
The Cellular Basis of B Cell Memory
Immunoglobulin assembly and secretion
Fc And Complement Receptors