Molecular Biology Of B Cells by Tasuku HonjoMolecular Biology Of B Cells by Tasuku Honjo

Molecular Biology Of B Cells

byTasuku HonjoEditorMichael Reth, Andreas Radbruch

Hardcover | December 22, 2014

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Molecular Biology of B Cells, Second Editionis a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes.

Molecular Biology of B Cells, Second Editionoffers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology,Molecular Biology of B Cells, Second Editionis the definitive resource, vital for researchers across molecular biology, immunology and genetics.

  • Covers signaling mechanisms regulating B cell differentiation
  • Provides information on the development of therapeutics using monoclonal antibodies and clinical application of Ab
  • Contains studies on B cell tumors from various stages of B lymphocytes
  • Offers an integrated view of all aspects of B cells to produce a normal immune response
Dr. Tasuku Honjo graduated from Kyoto University Faculty of Medicine in 1966 (M.D.). After obtaining his Ph.D. in Biochimistry (Dr. O. Hayaishi), he spent 4 years in the U.S.A. as a postdoctoral fellow first in Carnegie Institution of Washington (Dr. D. Brown), and then in NIH (Dr. P. Leder) where he initiated studies on immunoglobulin...
Title:Molecular Biology Of B CellsFormat:HardcoverDimensions:600 pages, 9.41 × 7.24 × 0.98 inPublished:December 22, 2014Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123979331

ISBN - 13:9780123979339

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Table of Contents

1. Ig loci: structure and expression regulation

2. The mechanisms of V(D)J recombination

3. Transcriptional regulation of B lymphocyte differentiation

4. B cell transcriptome

5. The role of microRNA in B cell development and function

6. Proliferation and differentiation program of developing B cells

7. Development and function of B cell subsets

8. Evolution of primordial B cell antigen receptor

9. The evolutionary origin of V(D)J diversification

10. Receptor organization on B cells and its signaling

11. Fc and complement responses

12. The dynamic structure of germinal center: generation of high affinity Ab

13. Cell Migration

14. B cell as regulator

15. B cell memory and plasma cell development

16. Roles of lymphotoxin and Baff on B cells

17. The mucosal immune system: host-bacteria interaction and regulation of IgA synthesis

18. Gut microbiota and their regulation

19. Regulation and function of activation-induced cytidine deaminase

20. Molecular mechanism of CSR

21. Molecular mechanism of SHM

22. Aberrant AID expression by pathogen infection

23. Chromosomal translocation and mutations in B cell leukemia and lymphomas

24. B cells producing pathogenic autoantibodies

25. HIV neutralizing Ab

26. Immune deficiency caused by B cell defects

27. IMGT® for immunoglobulin repertoire analysis and antibody humanization

28. Humanized monoclonal Ab production

29. Ab therapy against lymphoma

30. Anti-interleukin-6 receptor antibody therapy against autoimmune inflammatory diseases

31. Ab therapy against chronic inflammatory immune-mediated diseases