Molecular Biology Of B Cells

Hardcover | December 22, 2014

byTasuku HonjoEditorMichael Reth, Andreas Radbruch

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Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics. Covers signaling mechanisms regulating B cell differentiation Provides information on the development of therapeutics using monoclonal antibodies and clinical application of Ab Contains studies on B cell tumors from various stages of B lymphocytes Offers an integrated view of all aspects of B cells to produce a normal immune response

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Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular ...

Dr. Tasuku Honjo graduated from Kyoto University Faculty of Medicine in 1966 (M.D.). After obtaining his Ph.D. in Biochimistry (Dr. O. Hayaishi), he spent 4 years in the U.S.A. as a postdoctoral fellow first in Carnegie Institution of Washington (Dr. D. Brown), and then in NIH (Dr. P. Leder) where he initiated studies on immunoglobulin...

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Format:HardcoverDimensions:600 pages, 9.41 × 7.24 × 0.98 inPublished:December 22, 2014Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123979331

ISBN - 13:9780123979339

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Table of Contents

1. Ig loci: structure and expression regulation

2. The mechanisms of V(D)J recombination

3. Transcriptional regulation of B lymphocyte differentiation

4. B cell transcriptome

5. The role of microRNA in B cell development and function

6. Proliferation and differentiation program of developing B cells

7. Development and function of B cell subsets

8. Evolution of primordial B cell antigen receptor

9. The evolutionary origin of V(D)J diversification

10. Receptor organization on B cells and its signaling

11. Fc and complement responses

12. The dynamic structure of germinal center: generation of high affinity Ab

13. Cell Migration

14. B cell as regulator

15. B cell memory and plasma cell development

16. Roles of lymphotoxin and Baff on B cells

17. The mucosal immune system: host-bacteria interaction and regulation of IgA synthesis

18. Gut microbiota and their regulation

19. Regulation and function of activation-induced cytidine deaminase

20. Molecular mechanism of CSR

21. Molecular mechanism of SHM

22. Aberrant AID expression by pathogen infection

23. Chromosomal translocation and mutations in B cell leukemia and lymphomas

24. B cells producing pathogenic autoantibodies

25. HIV neutralizing Ab

26. Immune deficiency caused by B cell defects

27. IMGT® for immunoglobulin repertoire analysis and antibody humanization

28. Humanized monoclonal Ab production

29. Ab therapy against lymphoma

30. Anti-interleukin-6 receptor antibody therapy against autoimmune inflammatory diseases

31. Ab therapy against chronic inflammatory immune-mediated diseases