Molecular Diagnostics And Treatment Of Pancreatic Cancer: Systems And Network Biology Approaches by Asfar AzmiMolecular Diagnostics And Treatment Of Pancreatic Cancer: Systems And Network Biology Approaches by Asfar Azmi

Molecular Diagnostics And Treatment Of Pancreatic Cancer: Systems And Network Biology Approaches

byAsfar AzmiEditorAsfar Azmi

Hardcover | April 23, 2014

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Molecular Diagnostics and Treatment of Pancreatic Cancerdescribes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets. First of a kind and novel network strategies to understand oncogenic Kras signaling in pancreatic tumors are presented. The attempts to computationally model and prioritize microRNAs that cause pancreatic cancer resistance are also highlighted.

Addressing this important area,Molecular Diagnostics and Treatment of Pancreatic Cancerprovides insights into important network evaluation methodologies related to pancreatic cancer related microRNAs targetome. There are dedicated chapters on critical aspects of the evolving yet controversial field of pancreatic cancer stems cells. The work concludes by discussing the applications of network sciences in pancreatic cancer drug discovery and clinical trial design.



  • Encompasses discussion of innovative tools including expression signatures in cell lines, 3D models, animal xenograft models, primary models and patient derived samples, aiding subversion of traditional biology paradigms, and enhancing comprehension across conventional length and temporal scales
  • Coverage includes novel applications in targeted drugs, polypharmacology, network pharmacology and other related drug development arenas helping researchers in pancreatic cancer drug discovery
  • Summarizes many relevant computational and clinical references from fast-evolving literature
  • Comprehensive glossary helps newer readers understand technical terms and specialized nomenclature

About The Author

Dr. Asfar S. Azmi, PhD. is an Assistant Professor in the Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan USA. He has more than a decade of research experience in the area of cancer biology and drug discovery. His translational work broadly focuses on designing, developing and testing novel small mol...
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Details & Specs

Title:Molecular Diagnostics And Treatment Of Pancreatic Cancer: Systems And Network Biology ApproachesFormat:HardcoverDimensions:458 pages, 9.41 × 7.24 × 0.98 inPublished:April 23, 2014Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0124081037

ISBN - 13:9780124081031

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Table of Contents

  1. An Integrated Systems Approach to the Study of Pancreatic Cancer
  2. Systems Biology of Pancreatic Cancer: The Role of Tumor-Microenvironment Communication in Development, Progression and Therapy Resistance
  3. Proteomics of Pancreatic Cancer Stem Cells
  4. Systems and Network Guided Pancreatic Cancer Drugs
  5. Prioritizing Pancreatic Cancer Related miRNAs Using Systems Platform
  6. Pancreatic Proteome Guided Biomarker Discovery
  7. Proteomic Analysis of Pancreatic Biopsies
  8. RNAi Screen in Pancreatic Cancer Drug Development
  9. Modeling Apoptotic Signaling in Pancreatic Cancer
  10. Genetic, Epigenetic, and Proteomic Evaluation Post Laser Microdissection of Pancreatic Tumors
  11. Proteomic Analysis of Gemcitabine Toxicity
  12. Understanding Pancreatic Cancer through Proteomics of Stellate Cells in Rat Models
  13. Genome Wide CpG Profiling of Intraductal Papillary Mucinous Neoplasms of the Pancreas
  14. Proteomic Profiling of Archival Lesions in Pancreatic Cancer
  15. Computational Assessment of Benign and Potentially Malignant Pancreatic Cysts
  16. Pancreatic Cancer Pharmacogenomics
  17. Systems Biology on Pancreatic Splice Variants
  18. Systems and Network for Pancreatic Cancer Drug Discovery

Editorial Reviews

"...a well-written book on the use of cutting-edge technology in bioinformatics and computational modeling and how information from these assays can be used to discover new links between system elements in pancreatic cancer. Score: 77 - 3 Stars"--Doodys.com, January 30, 2015 "...describes the different emerging applications of systems biology that are shaping modern pancreatic cancer research...provides insights into important network evaluation methodologies related to microRNAs targetome..."--Anticancer Research, January 2015