Molecular Epidemiology

Paperback | November 1, 2001

EditorMary Carrington, Rus Hoelzel

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The 'molecular' aspect of molecular epidemiology refers to the application of molecular biological approaches to epidemiologic problems. The variety and power of molecular methods are rapidly expanding our capability to dissect etiologic mechanisms of disease. The 'epidemiologic' aspect,meanwhile, refers to utilizing the tools and perspectives of epidemiology to comprehend observations in molecular biology. An increasingly sophisticated variety of molecular techniques are being applied to generate an explosion of data on exposures and outcomes whose significance must be determined.The wealth of information generated by the Human Genome Project and the corresponding efforts in microbial genomics are providing researchers with extraordinary new opportunities to further understand the etiology of disease. Molecular epidemiology is rapidly evolving through the application of morerelevant markers of exposure and better identification of subgroups at increased risk of early disease processes and progression.This volume provides a broad overview of the diverse approaches encompassed by this emerging discipline. Chapters 1-3 highlight concepts and methods at the forefront of studies of infectious diseases, and include a synopsis of general epidemiologic design and analysis, as well as current techniquesfor molecular typing of microbial pathogens. Chapters 4-6 are focussed on recent advances in studying host genetics, including methods for the detection of mutations and polymorphisms, identification of linkage among alleles of genes on a given chromosome, and the use of DNA pooling to increaseefficiency in association studies of genetically complex traits. Chapters 7 and 8 deal with the relationship between pathologies and immune system genetics, and on the use of DNA sequence information to garner insights into the evolution of infectious pathogens, and into the evolution and functionof the immune system.

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The 'molecular' aspect of molecular epidemiology refers to the application of molecular biological approaches to epidemiologic problems. The variety and power of molecular methods are rapidly expanding our capability to dissect etiologic mechanisms of disease. The 'epidemiologic' aspect,meanwhile, refers to utilizing the tools and pers...

Mary Carrington is at National Cancer Institute, Frederick, Maryland, USA. Rus Hoelzel is at Department of Biological Sciences, University of Durham, UK.
Format:PaperbackDimensions:264 pages, 9.69 × 7.44 × 0.59 inPublished:November 1, 2001Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199638101

ISBN - 13:9780199638109

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Table of Contents

Charles Rabkin and Nathaniel Rothman: Introduction1. Eric A.Engels and Thomas R.O'Brien: Epidemiological methods for studies of genetic factors that influence infectious diseases2. Eric W.Brown: Molecular Differentiation of bacterial strains3. Shirley Kwok: Detection and quantification of heterogeneous viral targets: using HIV as a model4. Michael Dean, Bernard Gerrard and Rando Allikmets: Mutation Detection by Single-Stranded Conformation Polymorphism and Denaturing High Performance Liquid Chromatography5. Lisa F.Barcellos, Soren Germer and William Klitz: DNA Pooling Methods for association mapping of complex disease loci6. Michael Cullen and Mary Carrington: Single-sperm typing: a rapid alternative to family based linkage analysis7. Henry A.Erlich and Elizabeth A.Trachtenberg: PCR-based methods of HLA typing8. Austin L.Hughes, Jack da Silva and Federica Verra: Evolutionary Analysis of Molecular Sequence Data

Editorial Reviews

"This book provides both comprehensive background information and detailed protocols for the practical analysis of the aetiology of disease in the post Human Genome Project era. . .ÝS¨ections relevant to complex disease and the effective design of molecular genetic approaches make this a volume ofsignificant general interest."--International Journal of Epidemiology"Molecular methods have become integral to the study of most fields of biology. This book is an excellent introduction to their application to epidemiology. Intended as a reference guide for researchers rather than a textbook, it gives a concise account of current molecular biological methodsavailable to epidemiologists. . .Molecular Epidemiology was a delight to read and would be invaluable to postgraduates or as a textbook for an undergraduate module."--Journal of Biological Education"Seventeen specialists (16 Americans and one Italian) contribute eight chapters to this volume exploring the wide range of approaches being used in the field of molecular epidemiology. Coverage includes cutting-edge concepts and methods in the study of infectious diseases, with a synopsis of generalepidemiologic design and analysis, and current techniques for molecular typing of microbial pathogens; recent advances in studying host genetics, including methods for the detection of mutations and polymorphisms, identification of linkage among alleles of genes on a given chromosome, and the use ofDNA pooling to increase efficiency in association studies of genetically complex traits; the relationship between pathologies and immune system genetics; the use of DNA sequence information to gain insights into the evolution ofinfectious pathogens; and the evolution and function of the immunesystem."--SciTech Book News