Molecular Evolution: A Statistical Approach

Paperback | May 22, 2014

byZiheng Yang

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Studies of evolution at the molecular level have experienced phenomenal growth in the last few decades, due to rapid accumulation of genetic sequence data, improved computer hardware and software, and the development of sophisticated analytical methods. The flood of genomic data has generatedan acute need for powerful statistical methods and efficient computational algorithms to enable their effective analysis and interpretation.Molecular Evolution: a statistical approach presents and explains modern statistical methods and computational algorithms for the comparative analysis of genetic sequence data in the fields of molecular evolution, molecular phylogenetics, statistical phylogeography, and comparative genomics. Writtenby an expert in the field, the book emphasizes conceptual understanding rather than mathematical proofs. The text is enlivened with numerous examples of real data analysis and numerical calculations to illustrate the theory, in addition to the working problems at the end of each chapter. Thecoverage of maximum likelihood and Bayesian methods are in particular up-to-date, comprehensive, and authoritative. This advanced textbook is aimed at graduate level students and professional researchers (both empiricists and theoreticians) in the fields of bioinformatics and computational biology, statistical genomics, evolutionary biology, molecular systematics, and population genetics. It will also be ofrelevance and use to a wider audience of applied statisticians, mathematicians, and computer scientists working in computational biology.

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From the Publisher

Studies of evolution at the molecular level have experienced phenomenal growth in the last few decades, due to rapid accumulation of genetic sequence data, improved computer hardware and software, and the development of sophisticated analytical methods. The flood of genomic data has generatedan acute need for powerful statistical metho...

Ziheng Yang is currently RA Fisher Professor of Statistical Genetics in University College London. He obtained a Ph. D in agronomy in Beijing Agricultural University in 1992. Since then he held a few postdoctoral researcher positions in the UK and US. He joined UCL in 1997, first as a lecturer, then reader and professor. He teaches st...

other books by Ziheng Yang

Computational Molecular Evolution
Computational Molecular Evolution

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Format:PaperbackDimensions:528 pagesPublished:May 22, 2014Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199602611

ISBN - 13:9780199602612

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Table of Contents

1. Models of nucleotide substitution2. Models of amino acid and codon substitution3. Phylogeny reconstruction: overview4. Maximum likelihood methods5. Comparison of phylogenetic methods and tests on trees6. Bayesian theory7. Bayesian computation (MCMC)8. Bayesian phylogenetics9. Coalescent theory and species trees10. Molecular clock and estimation of species divergence times11. Neutral and adaptive protein evolution12. Simulating molecular evolutionAppendixesReferences