Molecular Mechanisms of Cancer by Georg F. WeberMolecular Mechanisms of Cancer by Georg F. Weber

Molecular Mechanisms of Cancer

byGeorg F. Weber

Paperback | November 10, 2010

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Cancer may constitute the most extensively studied functions constitute a second line of defense that disease entity of our time. Nevertheless, our com- protects against transforming defects in oncogenes prehension of the cellular and molecular pathology or tumor-suppressor genes and are here considered of malignant transformation is incomplete. In view as metasuppressor genes. Advances in the molecular of the diverse clinical presentations of various explanations of growth dysregulation, metastasis malignancies, doubts may be raised as to whether it formation, extension of life span, and loss of ma- is appropriate to refer to cancer as one group of dis- tenance of genomic and epigenetic integrity in ease states. The notion of malignant tumors as a cancer suggest models for their causal connection. pathologic and pathophysiologic class of conditions The mechanisms of growth control, senescence, and begs the question for defining criteria that charac- anchorage dependence are linked on the molecular terize all malignant growths, regardless of their tis- level (Chapter 8). In cells that are not fully differ- sue of origin. Toward this goal, the recognition that tiated, the overactivation of oncogene pathways tumor development is caused by the dysregulation also induces the expression of metastasis genes. of growth-controlling genes (oncogenes and tumor- Telomerase, the enzyme that prevents cell sen- suppressor genes) has advanced our mechanistic cence, is expressed in these precursor cells and may understanding of oncology (Chapter 3). However, be further activated by growth factor signaling.
Title:Molecular Mechanisms of CancerFormat:PaperbackDimensions:645 pagesPublished:November 10, 2010Publisher:Springer NatureLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9048175054

ISBN - 13:9789048175055

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Table of Contents

CONDENSED TABLE OF CONTENTS Introduction Section I. General Mechanisms Of Transformation 1. Theories of Carcinogenesis 2. Physiologic Correlates of Malignancy Section II. Alterations Intrinsic to the Tumor Cells 3. Cell Division and Survival 4. Cellular Senescence 5. Invasiveness Section III. Mechanisms of Regulation Of Cancer Related Genes 6. DNA Repair 7. Epigenetic Regulation of Cancer Associated Gene Products 8. Interaction of the Groups of Cancer Related Gene Products Section IV. Interactions between Host and Tumor 9. Structural Growth Control 10. The Organ Preference of Metastasis Formation 11. Angiogenesis 12. Interactions with The Immune System 13. Endocrine Dysregulation 14. Dormancy and Minimal Residual Disease Section V. Molecular Mechanisms of Individual Cancers 15. Epithelial Tumors 16. Hematologic Malignancies 17. Mesenchymal Tumors 18. Neurologic Tumors 19. Tumors of Serous Cavities 20. Embryonic Tumors

Editorial Reviews

"I have found this to be a comprehensive, yet highly focused text on malignancies. Dr. Weber's work covers nicely the interface of physiology and molecular mechanisms in the development and maintenance of malignant cells. The review of the founding pathologic observations is useful in providing a backdrop for today's highly molecular approaches. A deep understanding of the molecular workings of malignant disease is critical to the development of not only therapeutics, but also diagnostics and I have found this text to be highly relevant as a resource to these ends". Gary A. Pestano, PhD, Director, Discovery Life Sciences, Ventana Medical Systems, Inc., Tucson, Arizona USA"Whereas the field of cancer research has increased in complexity over the past decades, this book presents a comprehensive compendium of molecular mechanisms of malignancy and reflects the author's unique vision on pathophysiologic associations that may define general molecular requirements of invasive tumors. This book reaches beyond the current view and understanding of molecular mechanisms of malignancies and prompts the reader to reflect on the current knowledge from a different angle". Professor Dr. med. H.-P. Bruch, Head of the Department of Surgery, Klinik fuer Chirurgie, Univeritatsklinikum, Schleswig-Holstein, Luebeck, Germany