Molecular Mechanisms of Neurodegenerative Diseases by Marie-Francoise ChesseletMolecular Mechanisms of Neurodegenerative Diseases by Marie-Francoise Chesselet

Molecular Mechanisms of Neurodegenerative Diseases

EditorMarie-Francoise Chesselet

Paperback | November 9, 2010

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Marie-Françoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.
Title:Molecular Mechanisms of Neurodegenerative DiseasesFormat:PaperbackDimensions:423 pages, 9.02 × 5.98 × 0 inPublished:November 9, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617371971

ISBN - 13:9781617371974

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Table of Contents

Ab Toxicity in Alzheimer's Disease, William L. Klein. Transgenic Models of Alzheimer's Disease, Michael C. Sugarman, Steven F. Hinton, and Frank M. LaFerla. Glial Cells in Alzheimer's Disease, Robert E. Mrak and W. Sue T. Griffin. Inflammation in Alzheimer's Disease, Caleb E. Finch, Valter Longo, Aya Miyao, Todd E. Morgan, Irina Rozovsky, Yubei Soong, Min Wei, Zhong Xie, and Hadi Zanjani. Proteolysis in Neurodegenerative Diseases, Vivian Y. H. Hook and Liane Mende-Mueller. Treatment Approaches for Alzheimer's Disease, Michael Gold, Kevin M. Felsenstein, and Perry Molinoff. Tau and a-Synuclein in Neurodegenerative Diseases, Benoit I. Giasson, Christina A. Wilson, John Q. Trojanowski, and Virginia M. Y. Lee. PET Investigations of Parkinson's Disease, Tamara Hershey, Stephen M. Moerlein, and Joel S. Perlmutter. Dopamine Neurotoxicity and Neurodegeneration, BethAnn McLaughlin. Mitochondria and Parkinson's Disease, Russell H. Swerdlow. Pathophysiology of SCA1, Harry T. Orr and Huda Y. Zoghbi. Pathophysiology of SCA3, Puneet Opal and Henry Paulson. Pathophysiology of Spinal and Bulbar Muscular Atrophy, Diane E. Merry. Mouse Models of Huntington's Disease, Marie-Françoise Chesselet and Michael S. Levine. Huntington-Associated Proteins, Marcy E. MacDonald, Lucius Passani, and Paige Hilditch-Maguire. Modeling Neurodegenerative Diseases in the Fruit Fly, George R. Jackson. Index.

Editorial Reviews

"The reviews are well-written and well-edited so that they are accessible to both the researcher and non-researcher. The reviews examine a variety of current hypotheses as to the nature of neurodegeneration in a variety of conditions. . .This is a well-written book. Although no clear answers emerge, it shows the power of modern molecular methods in examining the underlying basis of these long baffling neurodegenerative disease. The practicing neurologist can only marvel at the power of the new molecular techniques that will soon reveal the underlying molecular basis of these disorders. This book clearly conveys the exciting advances that have already been made and hints at the advances that loom around the corner."-Doody's Health Sciences Book Review Journal