Molecular Mechanisms of Parasite Invasion by Barbara A. BurleighMolecular Mechanisms of Parasite Invasion by Barbara A. Burleigh

Molecular Mechanisms of Parasite Invasion

EditorBarbara A. Burleigh, Dominique Soldati

Paperback | November 19, 2010

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In biological terms, a parasite can be defined as "an organism that grows, feeds and is sheltered on, or in, a different organism while contributing nothing to the survival of the host."1 This relationship is particularly intimate for parasitic protozoa (and single-celled fungi such as the Microsporidia), many of which not only penetrate tissue barriers, but gain entry into host cells. The entry mechanisms are as diverse as the organisms employing them and are often critical components of their pathogenic profile. All of the parasitic organisms highlighted in this new book represent medically important human pathogens that contribute significantly to the global burden of disease. As such there is intense interest in understanding the molecular basis of infection by these pathogens-not only with regard to their clinical relevance but also the fascinating biology they reveal. For most of the parasites discussed here (Plasmodium falciparum, Toxoplasma gondii, Cryptosporidium parvum, Trypanosoma cruzi and Leishmania spp.) the ability to penetrate biological barriers and/or to establish intracellular residence is critical to survival of the pathogen in the mammalian hosts. For other parasites, such as Entamoeba, a tissue invasive phenotype is a key virulence determinant. In the ensuing 18 chapters, select members of this diverse set of protozoan parasites, as well as some examples of the extremely reduced fungal parasites classified as Microsporidia, are discussed within the context of the fascinating molecular strategies employed by these organisms to migrate across biological barriers and to establish residence within target host cells.
Title:Molecular Mechanisms of Parasite InvasionFormat:PaperbackDimensions:257 pages, 9.76 × 6.5 × 0.68 inPublished:November 19, 2010Publisher:Springer New YorkLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1441926836

ISBN - 13:9781441926838

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Table of Contents

TABLE OF CONTENTSPreface xxiSECTION I: TOOLS AND EXPERIMENTAL APPROACHES1. Current and Emerging Approaches to Studying Invasionin Apicomplexan Parasites 1Jeffrey Mital and Gary E. WardSECTION II: RECEPTOR-LIGAND INTERACTION2. Microneme Proteins in Apicomplexans 33Vern B. Carruthers and Fiona M. Tomley3. Erythrocyte Invasion by Plasmodium falciparum:Multiple Ligand-Receptor Interactions and Phenotypic Switching 46Manoj T. Duraisingh, Tiffany DeSimone, Cameron Jennings,Philippe Refour and Chenwei Wu4. Role of the gp85/Trans-Sialidase Superfamily of Glycoproteinsin the Interaction of Trypanosoma cruzi with Host Structures 58Maria Júlia M. Alves and Walter ColliSECTION III: SIGNALING PATHWAYS5. Calcium Regulation and Signaling in Apicomplexan Parasites 70Kisaburo Nagamune, Silvia N. Moreno, Eduardo N. Chiniand L. David Sibley6. Trypanosoma cruzi: Parasite and Host Cell Signalingduring the Invasion Process 82Nobuko Yoshida and Mauro CortezSECTION IV: ACTIN DYNAMICS: HOST AND PARASITE7. Host Cell Actin Remodeling in Response to Cryptosporidium 92Steven P. O'Hara, Aaron J. Small, Xian-Ming Chenand Nicholas F. LaRusso8. Host Cell Actin Remodeling in Response to Trypanosoma cruzi:Trypomastigote Versus Amastigote Entry 101Renato A. Mortara, Walter K. Andreoli, Maria Cecília D.C. Fernandes,Claudio V. da Silva, Adriana B. Fernandes, Carolina L'Abbate,and Solange da Silva9. Actin/Myosin-Based Gliding Motility in Apicomplexan Parasites 110Kai Matuschewski and Herwig SchülerSECTION V: PROTEASES10. Roles of Proteases during Invasion and Egress by Plasmodiumand Toxoplasma 121Timothy J. Dowse, Konstantinos Koussis, Michael J. Blackmanand Dominique Soldati-Favre11. Roles of Naturally Occurring Protease Inhibitors in the Modulationof Host Cell Signaling and Cellular Invasion by Trypanosoma cruzi 140Julio Scharfstein and Ana Paula C.A. LimaSECTION VI: THE PARASITOPHOROUS VACUOLE12. Biogenesis of and Activities at the Toxoplasma gondiiParasitophorous Vacuole Membrane 155Anthony P. Sinai13. The Role of Host Cell Lysosomes in Trypanosoma cruzi Invasion 165G. Adam Mott and Barbara A. Burleigh14. Leishmania Invasion and Phagosome Biogenesis 174Robert Lodge and Albert DescoteauxSECTION VII: PENETRATING BIOLOGICAL BARRIERS15. Plasmodium Sporozoite Passage across the SinusoidalCell Layer 182Ute Frevert, Ivan Usynin, Kerstin Baer and Christian Klotz16. Transepithelial Migration by Toxoplasma 198Antonio Barragan and Niclas Hitziger17. The Microsporidian Polar Tube and Its Role in Invasion 208Frédéric Delbac and Valérie Polonais18. Intestinal Invasion by Entamoeba histolytica 221Shahram Solaymani-Mohammadi and William A. Petri, Jr.Index 233

Editorial Reviews

From the reviews:"An environment in which there is extensive knowledge of the DNA, RNA and protein of key parasites and of human cells. . Readers of this book will discover that while many of the exact mechanisms . adopted by different parasites. As someone working in this field I found this book enormously interesting and useful . . Active researchers and PhD students in this and affiliated fields will no doubt find this an essential resource for several years . ." (Kevin M. Tyler, Parasites and Vectors, Issue 2, May, 2009)