Molecular Mechanisms of Synaptogenesis by Alexander DityatevMolecular Mechanisms of Synaptogenesis by Alexander Dityatev

Molecular Mechanisms of Synaptogenesis

byAlexander Dityatev

Paperback | October 29, 2010

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This book provides a new compilation of information that link changes in the basic structure of synapses and brain diseases. The book shows that specific secreted proteins, and short peptide mimicking the function of neural cell adhesion molecules can significantly enhance the formation of synapses in the brain. It describes recent advances in research that lay necessary scientific groundwork to develop pharmacological treatments.
Title:Molecular Mechanisms of SynaptogenesisFormat:PaperbackDimensions:497 pagesPublished:October 29, 2010Publisher:Springer NatureLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1441940901

ISBN - 13:9781441940902

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Table of Contents

Synaptogenesis: When Long-Distance Relations Become Intimate.- Synaptogenesis: When Long-Distance Relations Become Intimate.- Experimental Models of Synaptogenesis.- The Formation of the Vertebrate Neuromuscular Junction: Roles for the Extracellular Matrix in Synaptogenesis.- Synapse Formation between Identified Molluscan Neurons: A Model System Approach.- Development of the Drosophila and C. Elegans Neuromuscular Junctions.- Mechanisms That Regulate Neuronal Protein Clustering at the Synapse.- Roles of Cell Adhesion and Secreted Molecules in Synaptic Differentiation.- Cadherin-Mediated Adhesion and Signaling During Vertebrate Central Synapse Formation.- Synaptic Functions of the Neural Cell Adhesion Molecule, NCAM.- Role of Neuroligin Binding to Neurexins in Synaptic Organization.- SynCAM in Formation and Function of Synaptic Specializations.- Protocadherins and Synapse Development.- Ephrins and Eph Receptors in Spinogenesis and Synaptic Plasticity.- Extracellular Matrix Molecules and Formation of CNS Synapses.- Role of Neurotrophins in the Formation and Maintenance of Synapses.- Transport of Synaptic Proteins.- Motor-Cargo Interactions Involved in Transport of Synaptic Proteins.- Postsynaptic Transport Packets.- Lateral Diffusion of Excitatory Neurotransmitter Receptors During Synaptogenesis.- Synaptic Cytoskeleton and Morphogenic Signaling.- Assembly of Presynaptic Active Zones.- Assembly of Postsynaptic Protein Complexes in Glutamatergic Synapses.- Regulation of Dendritic Spine Morphology and Synaptic Function By Scaffolding Proteins.- Composition and Assembly of Gabaergic Postsynaptic Specializations.- Role of Synaptogenesis in Morphologic Stabilization of Developing Dendrites.- Protein Kinases and Synaptogenesis.- Signaling from Synapse to Nucleus and Back.- Synaptic Plasticity in Learning and Memory.- Structural Synaptic Correlates of Learning and Memory.- Intracellular Trafficking of AMPA-Type Glutamate Receptors.- Learning-Induced Changes in Sensory Synaptic Transmission.- Synaptogenesis and Brain Disorders.- Relevance of Presynaptic Proteins to Neuropsychiatric Disorders.- Synaptic Abnormalities and Candidate Genes in Autism.- Synaptic Pathology in Depression.- Synaptic Pathology in Dementia.- A Fragile Synapse: Changes at the Synapse in Fragile X Syndrome.- Synaptic Abnormalities Associated with Huntington's Disease.- Interference Peptides: A Novel Therapeutic Approach Targeting Synaptic Plasticity in Drug Addiction.

Editorial Reviews

From the reviews:"This volume provides a comprehensive overview and perspectives on the interplay between development, maturity, and disease that is valuable to the newcomer and expert alike. One strength of this volume is that it highlights the breadth of the many experimental systems and approaches that are used to study normal development as well as synaptic defects associated with human diseases. . This volume provides an excellent resource to both established investigators and newcomers to the field." (Ethan G. Hughes and Rita J. Balice-Gordon, Neuron, Vol. 53, 2007)