Molecular Pathology: The Molecular Basis of Human Disease

Other | February 10, 2009

byWilliam B. Coleman, William B. Coleman, Gregory J. Tsongalis

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Molecular Pathology: The Molecular Basis of Human Disease provides a current and comprehensive view of the molecular basis and mechanisms of human disease. Combining accepted principles with broader theoretical concepts and with contributions from a group of experts, the book looks into disease processes in the context of traditional pathology and their implications for translational molecular medicine. It also discusses concepts in molecular biology and genetics, recent scientific and technological advances in modern pathology, the concept of "molecular pathogenesis" of disease, and how disease evolves from normal cells and tissues due to perturbations in molecular pathways.
The book describes the integration of molecular and cellular pathogenesis using a bioinformatics approach and a systems biology approach to disease pathogenesis. It also discusses current and future strategies in molecular diagnosis of human disease, and the impact of molecular diagnosis on treatment decisions and the practice of personalized medicine.
This book is a valuable resource for students, biomedical researchers, practicing physician-scientists who undertake disease-related basic science and translational research, and pathology residents and other postdoctoral fellows.

* Exam Master® web site will host "Self-assessment" questions that students can use to study for the molecular section of the board exam
* Companion Web Site - will host a complete set of PowerPoint slides: to include images from the book and additional images for teaching; course materials; lecture materials
* Teaches from the perspective of "integrative systems biology," which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease
* Outlines the principles and practice of molecular pathology
* Explains the practice of "molecular medicine" and the translational aspects of molecular pathology

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Molecular Pathology: The Molecular Basis of Human Disease provides a current and comprehensive view of the molecular basis and mechanisms of human disease. Combining accepted principles with broader theoretical concepts and with contributions from a group of experts, the book looks into disease processes in the context of traditional p...

Gregory J. Tsongalis, Ph.D., H.C.L.D., C.C. is Professor of Pathology, Director, Molecular Pathology, and Co-Director Translational Research Program, Department of Pathology, Dartmouth Hitchcock Medical Center and The Audrey and Theodor Geisel School of Medicine at Dartmouth, Lebanon, NH, USA

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Format:OtherDimensions:664 pages, 1 × 1 × 1 inPublished:February 10, 2009Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080922198

ISBN - 13:9780080922195

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Table of Contents

PART I: Essential Pathology - Mechanisms of Disease
Molecular Mechanisms of Cell Death
Acute and Chronic Inflammation
Infection and Host Response
Neoplasia


PART II: Concepts in Molecular Biology and Genetics
Basic Concepts in Human Molecular Genetics
The Human Genome: Implications for the Understanding of Human Disease
The Human Transcriptome: Implications for the Understanding of Human Disease
The Human Epigenome: Implications for the Understanding of Human Disease
The Human Proteome: Implications for the Understanding of Human Disease
Integrative Systems Biology: Implications for the Understanding of Human Disease


PART III:Principles and Practice of Molecular Pathology
Pathology: The Clinical Description of Human Disease
Molecular Pathogenesis: The Biological Basis of Human Disease
Integration of Molecular and Cellular Pathogenesis


PART IV: Molecular Pathology of Human Disease
Molecular Basis of Cardiovascular Disease
Molecular Basis of Hemostatic and Thrombotic Diseases
Molecular Basis of Lymphoid and Myeloid Diseases
Molecular Basis of Diseases of Immunity
Molecular Basis of Pulmonary Disease
Molecular Basis of Diseases of the Gastrointestinal Tract
Molecular Basis of Liver Disease
Molecular Basis of Diseases of the Exocrine Pancreas
Molecular Basis of Diseases of the Endocrine System
Molecular Basis of Gynecologic Diseases
Molecular Basis of Prostate Disease
Molecular Basis of Breast Disease
Molecular Basis of Skin Disease
Molecular Basis of Diseases of the Nervous System


PART V: Practice of Molecular Medicine
Molecular Diagnosis of Human Disease
Molecular Assessment of Human Disease in the Clinical Laboratory
Pharmacogenomics and Personalized Medicine in the Treatment of Human Disease