Molecular Targets In Protein Misfolding And Neurodegenerative Disease

Paperback | October 30, 2017

byPierfausto Seneci

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Aimed at "drug discoverers" i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc. and a drug discovery-oriented, overall evaluation of each target validation, druggability, existing leads, etc. . Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc. Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases Provides a drug discovery application oriented perspective, evaluating targets and candidates for their overall therapeutic potential Provides discipline-specific chapters medicinal chemistry, target validation, preclinical and clinical development Provides an overview on a number of molecular mechanisms e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc. with relevance for any disease area Contains a more thorough description of the therapeutic relevance of

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Aimed at "drug discoverers" i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage paragraphs on medicina...

Dr. Pierfausto Seneci is Associate Professor in the Department of Organic and Industrial Chemistry at the University of Milan. He is currently affiliated with the University of Milan Centre for Interdisciplinary Biomolecular Studies and Industrial Applications (CISI) Centre of Excellence, and is responsible for the Combinatorial Chemis...

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Format:PaperbackDimensions:314 pages, 8.75 × 6.35 × 0.68 inPublished:October 30, 2017Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128103183

ISBN - 13:9780128103180

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Table of Contents

Chapter 1 Protein misfolding, neurodegeneration and Tau: The main players, or the usual suspects? Chapter 2 Targeting the protein quality control (PQC) machinery: The neuronal Salvation Army. Chapter 3 Proteasomal degradation of soluble, misfolded proteins: Throwing out the bath water, but where's the baby? Chapter 4 Unselective disposal of cellular aggregates: Engulf, devour and digest to recycle. Chapter 5 Selective disposal of insoluble protein aggregates: Pick, transport and remove to cure. Chapter 6 Assembly and disassembly of protein aggregates: Unraveling the maze. Conclusion