Molecular Toxicology

Hardcover | February 23, 2006

byP. David Josephy, Bengt Mannervik

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The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxins and foreign compounds on living things atthe molecular, cellular, and organismal levels. Breakthrough research has recently been completed illuminating the human genome and the role of enzymes in toxic biochemical reaction mechanisms. Toxicology now covers drug metabolism and design, carcinogenesis, programmed cell death, and DNA repair,among other subjects. The second edition captures these and other advances, and broadens its scope to address the experimental science of toxicology. The first edition of Molecular Toxicology has become an indispensable resource for graduate students in molecular and biochemical toxicology courses,as well as academic researchers and industrial researchers in toxicology. Rigorously updated and revised, the new edition commands an unrivaled authority in the field of molecular toxicology.

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The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxins and foreign compounds on living things atthe molecular, cellular, and organismal leve...

P. David Josephy is Professor of Molecular and Cellular Biology at the University of Guelph. Bengt Mannervik is the Karin and Herbert Jacobsson Professor of Biochemistry at Uppsala University, Sweden.
Format:HardcoverDimensions:608 pages, 7.28 × 10.12 × 1.5 inPublished:February 23, 2006Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195176200

ISBN - 13:9780195176209

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Table of Contents

Part One: Toxicity at the Cellular Level1. Toxicology of Oxygen2. Covalent Binding of Xenobiotics to DNA and Protein3. DNA Repair4. Chemical Mutagenesis5. Oncogenes, Tumor Suppressor Genes, and Mutations in Cancer Cells6. Toxicity, Survival, and Target TheoryPart Two: Enzymology of Biotransformation7. Cytochrome P450: Chemical and Biochemical Aspects8. P450: Biological Aspects, Regulation, Genetics9. Biochemistry of Glutathione10. Glutathione Transferases11. Glutathione and Glutathione Transferases: Toxicological and Pharmacological Aspects12. Glucuronic Acid Conjugation13. Arylamine N-Acetyltransferase14. SulfotransferasePart Three: Molecular Principles Applied to Specific Toxicants15. Alkylating Agents and "Mustards"16. Oxidative Stress in the Erythrocyte: Congenital and Xenobiotic-Induced Methemoglobinemia17. Aromatic Amines and Related Toxic Compounds18. Polycyclic Aromatic Hydrocarbon Carcinogens19. Acetaminophen