The daily life impact of movement disorders on people affected ranges from the inconvenient to major quality of life issues, depending upon the disorder and its progression. Topics in this issue of Neurologic Clinics address: Pathogenic Nechanisms of Neurodegeneration in Parkinson’s Disease; Treatment Strategies in Early and Advanced Parkinson’s Disease; Atypical Parkinsonism; Medical and Surgical Treatment of Tremors; Diagnosis and Treatment of Dystonia; Huntington’s Disease: Pathogenesis and Treatment; Tics and Tourette Syndrome; Paroxysmal Movement Disorders; Drug-induced Movement Disorders; Wilson Disease and other Neurodegenerations with Metal Accumulations; Psychogenic Movement Disorders; Ataxia; Gait Disorders; and Movement Disorders in Systemic Diseases. Videos are planned for the majority of the presentations and each article presents an Overview, Imaging, Pathology, and Diagnostic Dilemmas. The editor of this issue of Neurologic Clinics, Dr. Joseph Jankovic, is well known as expert in the pathophysiology, diganosis, and management of movement disorders - he has served as president of the international Movement Disorder Society and is recipient of numerous research awards related to these disorders. Dr Jankovic has involved world renown experts as authors in this publication.