mTOR Pathway and mTOR Inhibitors in Cancer Therapy by Vitaly A. PolunovskymTOR Pathway and mTOR Inhibitors in Cancer Therapy by Vitaly A. Polunovsky

mTOR Pathway and mTOR Inhibitors in Cancer Therapy

EditorVitaly A. Polunovsky

Paperback | October 13, 2012

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mTOR Pathway and mTOR Inhibitors in Cancer Therapy provides an up-to-date survey of the rapidly advancing field of cancer therapy. Our understanding of the mechanisms involved in cancer genesis and progression underwent unprecedented expansion during the last decade, opening a new era of cancer treatment - targeted therapy. The surge in this area results in no small part from studies conducted jointly by basic health scientists and clinical investigators. It is our hope that this book will help foster even further collaboration between investigators in these two disciplines. In this work, experts in TOR signaling have contributed in two thematic areas: mTOR Signaling and Cancer Therapy (chapters 1 - 8) and Therapeutic Targeting Downstream of mTOR (chapter 9 - 13). All chapters of mTOR Pathway and mTOR Inhibitors in Cancer Therapy are completely new or have been extensively updated by their authors; and we are indebted to all authors who have exemplified the links between these 2 thematic areas.
Title:mTOR Pathway and mTOR Inhibitors in Cancer TherapyFormat:PaperbackDimensions:316 pagesPublished:October 13, 2012Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617796948

ISBN - 13:9781617796944

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Table of Contents

1. N. Kubica and J. Blenis "mTORC1: A signaling integration node involved in cell growth"2. Z. Feng and A.J. Levine "The Regulation of the IGF-1/mTOR Pathway by the p53 Tumor Suppressor Gene Functions"3. H. Mead, M. Zeremski and M. Guba "mTOR Signaling in Angiogenesis"4. J. Brugaroles "mTOR signaling and hypoxia"5. D. Akhavan and P.S. Mischel "mTOR signaling in Glioblastoma: Lessons learned from bench to bedside"6. P. Houghton "mTOR and cancer therapy: General Principles"7. S. Faivre, T. Decaens and E. Raymond "mTOR and cancer therapy: Clinical development and novel prospects" 8. M. Breuleux and H. Lane "Drug combinations as a therapeutic approach for mTORC1 inhibitors in human cancer"9. B. D. Fonseca and C.G. Proud "Downstream targets of mTORC1"10. R. J. O. Dowling and N. Sonenberg "Downstream of mTOR: Translational control of cancer"11. O. Larsson and P.B. Bitterman "Genome-wide analysis of translational control"12. P.B. Bitterman and V.A. Polunovsky "Translational Control of Cancer: Implications for Targeted Therapy" 13. J. Pelletier and J.R. Graff "Downstream from mTOR: Therapeutic Approaches to targeting the eIF4F translation initiation complex"