Multiple Sclerosis: Clinician's Guide to Diagnosis and Treatment by Gary L. BirnbaumMultiple Sclerosis: Clinician's Guide to Diagnosis and Treatment by Gary L. Birnbaum

Multiple Sclerosis: Clinician's Guide to Diagnosis and Treatment

byGary L. Birnbaum

Paperback | April 2, 2013

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Multiple Sclerosis (MS) is an inflammatory, often progressive, and potentially disabling disease of the central nervous system. Onset of disease is usually between the ages of 15 and 50, with the incidence nearly twice as high in women. While the cause of MS is still unknown, the predominanttheory is that it is an autoimmune disease, triggered by an unknown environmental factor that results in both loss of central nervous system myelin and degeneration of axons and neurons. Although there have been a number of publications addressing different aspects of MS treatment in the neurological literature, there is a dearth of material on MS designed for internists and primary care physicians, who are often the first to see patients presenting with symptoms of MS. Therefore,this concise, clinically focused volume will serve as a valuable resource tailored to the specific needs of internists and primary care physicians. Part of the Oxford Neurology Library, this highly practical pocketbook covers current approaches and new developments in the diagnosis, treatment and management of MS, including both early and advanced stages of the disease. The book offers in-depth coverage of special populations, as well as themore unusual manifestations of MS, which are less familiar to the internal medicine audience. It will also address the role of imaging studies in the diagnosis, differential diagnosis and monitoring of the progression of MS. In addition to providing up-to-date information on pharmacologicaltherapies for MS, the book also describes an array of non-pharmacological treatment options.

About The Author

Gary L. Birnbaum is Director of the Multiple Sclerosis Treatment and Research Center at the Minneapolis Clinic of Neurology and Clinical Profesor of Neurology at the University of Minnesota School of Medicine, Minneapolis, Minnesota.

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Title:Multiple Sclerosis: Clinician's Guide to Diagnosis and TreatmentFormat:PaperbackDimensions:128 pages, 8 × 5 × 0.68 inPublished:April 2, 2013Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199840784

ISBN - 13:9780199840786

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Table of Contents

Introduction1. A Brief History of Multiple Sclerosisa.Experimental Autoimmune Encephalomyelitis2. Factors Involved in Causing Multiple Sclerosisa.Epidemiologyb.Causes of MSc.Immunology3. The Patterns and Pathophysiology of Multiple Sclerosisa.Patterns of MSb.Pathophysiology of MS4. Imaging of the Central Nervous System in Multiple Sclerosisa.Standard X-Ray Imaging of the Skull and Spinal Columnsb.Computed Tomography (CT) Imaging of the CNSc.Magnetic Resonance Imaging5. Making a Diagnosis of Multiple Sclerosisa.Patterns of Disease Presentationb.Demographicsc.Genetics of MSd.Initial Clinical Symptoms in Persons with Relapsing-Remitting MSe.Initial Clinical Symptoms of Primary-Progressive MSf.Presenting Signs in MSg.Magnetic Resonance Imagingh.Evoked Responsesi.Cerebrospinal Fluid Analysisj.Ruling Out "MS Look-alikes"k.Algorithms for the Diagnosis of MSl.Imparting a Diagnosis of MS6. Complications and Comorbidities of Multiple Sclerosisa.Loss of Bone Density (Osteopenia or Osteoporosis)b.Sleep Apnea and Other Altered Sleep Patternsc.Mood Disturbancesd.Urinary Tract and Other Infectionse.Sexual Dysfunctionf.Skin Lesionsg.Joint Dysfunctionh.Obesity7. Relapses of Multiple Sclerosis and Their Treatmenta.What Constitutes a Relapse?b.Conventional Relapse Treatmentsc.Unconventional Relapse Treatmentsd.Relapse Prevention8. Long-Term Disease-Modifying Therapiesa.Issues with Long-Term Immune-Modulating Therapiesb.Beta-Interferonsc.Glatiramer Acetated.Second-Line Disease-Modifying Therapiese.When Should Long-Term Immune-Modulating Therapy Be Stopped?f.Future Therapies9. Management of Multiple Sclerosis Symptomsa. Fatigueb.Depressionc.Paind.Spasticitye.Sexual Dysfunctionf.Conclusion10. Complementary Therapies for Multiple Sclerosisa.Physical Therapyb.Exercise Physiologistsc.Occupational Therapyd.Psychiatrists, Counselors, and Psychologistse.Neuropsychologistsf.Orthotistsg.Neuro-Ophthalmologistsh.Urologistsi.Social Workersj.Diet, Nutrition, and Food Supplements11. Gender Issues and Special Multiple Sclerosis Populationsa.Womenb. Menc.Children of Parents with MSd.Pediatric MS12. Resourcesa.Web Sitesb.Patient Advocacy Organizationsc.Sites for Disease-Modifying Therapiesd.Site for MR Imaging Protocol for MSe.Patient Books and MaterialsIndex