Muscarinic Receptor Subtypes in the GI Tract by G. LuxMuscarinic Receptor Subtypes in the GI Tract by G. Lux

Muscarinic Receptor Subtypes in the GI Tract

byG. LuxEditorE.E. Daniel

Paperback | November 20, 2011

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The differentiation between the muscarinic and the nicotinic ef­ fects of acetylcholine led to the subdivision of the cholinergic ner­ vous system into two categories. Further studies showed that stimu­ lating and inhibiting muscarinic effects could be demonstrated in different organs. For instance, gastric secretion and gastrointestinal motility are stimulated, while heart rate and the vascular muscula­ ture are inhibited. For decades, it could not be determined whether the various ef­ fects were mediated by different subgroups of muscarinic receptors, but eventually, with the availability of agonists and antagonists to muscarinic receptors, and using various techniques, the existence of at least two such subgroups could be ascertained . . Mt receptors are defined by their high affinity for the antagonist pirenzipine in comparison to M2 receptors. This subdivision of muscarinic receptors has since been proved beyond doubt by experi­ ments in vivo and in vitro, by receptor binding studies, by histoauto­ radiography, and by electrophysiological studies. However, these different classes of muscarinic receptors have not been found to relate to different types of effects; instead both excit­ atory and inhibitory effects appear to be linked to each class. For ex­ ample, excitation of gut motility and inhibition of cardiac contrac­ tile activities both appear to be mediated by M2 receptors, while ex­ citation of some nerves in sympathetic ganglia and inhibition of some myenteric nerves may be mediated by M receptors.
Title:Muscarinic Receptor Subtypes in the GI TractFormat:PaperbackDimensions:86 pages, 24.4 × 17 × 0.07 inPublished:November 20, 2011Publisher:Springer NatureLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3642706703

ISBN - 13:9783642706707

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Table of Contents

Autoradiographic Localization of Muscarinic Receptors in the Gut.- Functional and Biochemical Evidence for Muscarinic Receptor Subtypes in the Gastrointestinal Tract.- Selective Inhibition of Muscarinic Receptors in Intestinal Smooth Muscle.- Muscarinic Receptors on Neurones of the Submucous Plexus.- The Muscarinic Receptor Subtype on Gastric Isolated Smooth Muscle Cells.- Subtypes of Muscarinic Receptors Modulating Acetylcholine Release from Myenteric Nerves.- M1 and M2 Muscarinic Receptor Subtypes in the Lower Esophageal Sphincter.- Muscarinic Receptors and Exocrine Pancreatic Secretion.- Muscarinic M1-Receptor-Antagonists in Health and Disease.- Peptidergic Activation of Muscarinic M1 Inhibition in the Canine Small Intestine in Vivo.- Pirenzepine and Gastrointestinal Motility: Differential Effect of Pirenzepine in the Gut.