Mutation Detection: A Practical Approach

Paperback | March 1, 1998

EditorR. G. H. Cotton, E. Edkins, S. Forrest

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Mutation detection is increasingly undertaken in a wide spectrum of research areas: in medicine it is fundamental in isolating disease genes and diagnbosis, and is especially important in cancer research; in biology, commercially important genes can be identified by the mutations they contain.But mutation detection is time-consuming and expensive. This volume offers the latest tried and tested protocols for a range of detection methods, from the labs of the leading researchers in the field.

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Mutation detection is increasingly undertaken in a wide spectrum of research areas: in medicine it is fundamental in isolating disease genes and diagnbosis, and is especially important in cancer research; in biology, commercially important genes can be identified by the mutations they contain.But mutation detection is time-consuming an...

R. G. H. Cotton is at Mutation Research Centre, Victoria. E. Edkins is at Joint Women's and Children's Hospital, Perth.

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Format:PaperbackDimensions:262 pages, 9.21 × 6.14 × 0.59 inPublished:March 1, 1998Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0199636567

ISBN - 13:9780199636563

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Table of Contents

1. Single strand conformation polymorphism analysis2. Single-stranded conformation polymorphism and heteroduplex analysis3. Comprehensive mutation detection with denaturing gradient gel electrophoresis4. Cleavage using RNase to detect mutations5. Cleavage of mismatched bases using chemical reagents6. Mutation detection using T4 endonuclease VII7. Detection of mutations by hybridization with sequence-specific oligonucleotide probes8. DNA detection and sequence distinction through oligonucleotide ligation9. Detection of sequence variation using primer extension10. Selective amplification of specific alleles11. The protein truncation text (PTT)12. Functional assay of the p53 tumour suppressor gene13. Advances in direct DNA sequencing for mutation scanning

Editorial Reviews

`'...will provide a valuable resource both for those new to the area and for more experienced mutation detectives...''Trends in Genetics vol.15, no.1