Mutation-Driven Evolution

Paperback | October 24, 2014

byMasatoshi Nei

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The purpose of this book is to present a new mechanistic theory of mutation-driven evolution based on recent advances in genomics and evolutionary developmental biology. The theory asserts, perhaps somewhat controversially, that the driving force behind evolution is mutation, with naturalselection being of only secondary importance. The word "mutation" is used to describe any kind of change in DNA such as nucleotide substitution, gene duplication/deletion, chromosomal change, and genome duplication. A brief history of the principal evolutionary theories (Darwinism, mutationism, neo-Darwinism, and neo-mutationism) that preceded the theory of mutation-driven evolution is also presented in the context of the last 150 years of research. However, the core of the book is concerned with recent studiesof genomics and the molecular basis of phenotypic evolution, and their relevance to mutation-driven evolution. In contrast to neo-Darwinism, mutation-driven evolution is capable of explaining real examples of evolution such as the evolution of olfactory receptors, sex-determination in animals, andthe general scheme of hybrid sterility. In this sense the theory proposed is more realistic than its predecessors, and gives a more logical explanation of various evolutionary events.Mutation-Driven Evolution is suitable for graduate level students as well as professional researchers (both empiricists and theoreticians) in the fields of molecular evolution and population genetics. It assumes that the readers are acquainted with basic knowledge of genetics and molecularbiology.

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The purpose of this book is to present a new mechanistic theory of mutation-driven evolution based on recent advances in genomics and evolutionary developmental biology. The theory asserts, perhaps somewhat controversially, that the driving force behind evolution is mutation, with naturalselection being of only secondary importance. Th...

Masatoshi Nei is a molecular evolutionary geneticist and has developed many statistical methods that are widely used for evolutionary studies at present. He has also studied human evolution and evolution of multigene families, immune systems genes, sensory receptor genes, etc. Masatoshi Nei is currently Evan Pugh Professor of Biology a...

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Format:PaperbackDimensions:244 pages, 9.69 × 7.44 × 0.68 inPublished:October 24, 2014Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198724101

ISBN - 13:9780198724100

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Table of Contents

1. Selectionism and Mutationism2. Neo-Darwinism and Pan-Selectionism3. Evolutionary Theories in the Neo-Darwinian Era4. Molecular Evolution5. Gene Duplication, Multigene Families, and Repetitive DNA Sequences6. Evolution of Phenotypic Characters7. Mutation and Selection in Speciation8. Adaptation and Evolution9. Mutation and Selection in Evolution10. Summary and Conclusion