Myasthenia Gravis and Myasthenic Disorders

Hardcover | March 13, 2012

EditorAndrew G. Engel

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Myasthenia Gravis and Myasthenic Disorders, Second Edition is a thoroughly re-written and updated version of the highly successful first edition published in 1999. The current edition begins with an overview of the anatomy and molecular architecture of the neuromuscular junction and theelectrophysiologic diagnosis of its disorders. The introductory chapters are followed by a detailed exposition of the pathogenesis, natural history, diagnosis and therapy of the autoimmune myasthenias, the Lambert-Eaton myasthenic syndrome, and the increasingly complex and fascinating diseasescollectively referred to as congenital myasthenic syndromes. The acetylcholine receptor is a major target of both autoimmune and inherited myasthenias and a separate chapter reviews its structural and functional properties. The book also describes disorders that often target terminal nerve segmentnear the neuromuscular junction - the syndrome of peripheral nerve hyperexcitability and the Guillain-Barre syndrome. Comprehensively written by leaders at the forefront of research, not to mention thoroughly referenced throughout and gorgeously illustrated, this new edition of the classic 1999 text will cement its place as the text on Myasthenia Gravis and related disorders for years to come.

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Myasthenia Gravis and Myasthenic Disorders, Second Edition is a thoroughly re-written and updated version of the highly successful first edition published in 1999. The current edition begins with an overview of the anatomy and molecular architecture of the neuromuscular junction and theelectrophysiologic diagnosis of its disorders. Th...

Dr. Andrew Engel is the McKnight-3M Professor of Neuroscience and Professor of Neurology, Mayo Clinic College of Medicine as well as the Director of the Neuromuscular Disease laboratory at the Mayo Clinic, Rochester, MN campus. He earned his medical degree at McGill University, was trained in Neurology at the NIH and the Mayo Clinic ...

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Format:HardcoverDimensions:304 pages, 10 × 7 × 0.98 inPublished:March 13, 2012Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:019973867X

ISBN - 13:9780199738670

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Table of Contents

1. Andrew G. Engel, MD: The Anatomy and Molecular Architecture of the Neuromuscular,2. C. Michel Harper, MD: Electrodiagnosis of Myasthenic Disorders3. Reinhard Hohlfeld, Hartmut Wekerle, and Alexander Marx: The Immunopathogenesis of Myasthenia Gravis,4. Vladimir Luchanok, MD, PhD, and Henry J. Kaminski, MD: Natural History of Myasthenia Gravis5. James F. Howard, JR., M.D.: The Diagnosis of Myasthenia Gravis and Other Disorders of Neuromuscular Transmission6. Daniel B. Drachman, M.D.: Therapy of Myasthenia Gravis7. Vern C. Juel, M.D., and Donald B. Sanders, M.D.: The Lambert-Eaton Myasthenic Syndrome8. Andrew G. Engel, M.D., Xin-Ming Shen, Ph.D., Kinji Ohno, M.D., Ph.D, Steven M. Sine, Ph.D.: Congenital Myasthenic Syndromes9. Steven M. Sine and Andrew G. Engel: End-Plate Acetylcholine Receptor, a Target for Myasthenic Disorders: Structural and Mechanistic Essentials10. Srikanth Muppidi, M.D. and Steven Vernino, M.D., Ph.D.: Peripheral Nerve Hyperexcitability Syndromes11. Jaap J. Plomp and Hugh J. Willison: Effects of Antiganglioside Antibodies at the Neuromuscular Junction