Myocardial Damage: Early Detection by Novel Biochemical Markers by Juan Carlos KaskiMyocardial Damage: Early Detection by Novel Biochemical Markers by Juan Carlos Kaski

Myocardial Damage: Early Detection by Novel Biochemical Markers

EditorJuan Carlos Kaski, David W. Holt

Paperback | December 15, 2010

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The early detection of myocardial damage is one of the major challenges in contemporary cardiology. New biochemical markers have now emerged which appear to be highly sensitive and specific for the assessment not only of patients with myocardial infarction but also of those with unstable angina and prolonged chest pains. Some of these markers, such as the troponins, have been shown to have prognostic value in the context of acute chest pain. The incorporation of novel markers of myocardial damage to the routine diagnostic armamentarium is not without difficulty. The reasons for this include cost-benefit implications and the lack of definitive comprehensive publications dealing specifically with these issues. Technical difficulties with some of the novel markers are also a problem in some cases and this issue also needs to be carefully reviewed. A critical analysis of the biochemical characteristics, sensitivity and specificity as well as the potential clinical applications of the new markers is required. This monograph addresses these issues and also sets up the basis for a redefinition of myocardial damage and myocardial infarction. The book will be of particular interest to biochemists, pharmacologists, cardiologists, general physicians and clinical and basic researchers. The important issue of myocardial damage in relation to pharmacological agents has been specifically addressed in the book and this topic will be of particular interest to both clinical pharmacologists and those working in the pharmaceutical industry. International authorities, whose original work and expertise in the field are widely recognised, have contributed chapters to the book.
Title:Myocardial Damage: Early Detection by Novel Biochemical MarkersFormat:PaperbackDimensions:231 pages, 10.98 × 8.27 × 0.03 inPublished:December 15, 2010Publisher:Springer NetherlandsLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9048150566

ISBN - 13:9789048150564

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Table of Contents

Foreword; K. Thygesen. Preface. 1. Cellular Mechanisms of Ischaemic Myocardial Damage; G.F. Baxter. 2. Creatine Kinase (CK-MB)Isoforms; D.W. Holt. 3. Myocardial Damage: The Role of Troponin T; N. Frey, et al. 4. Troponin I: Structure, Physiology and its Role in Risk Stratification of Angina Patients; M. Plebani, M. Panteghini. 5. Myoglobin; J. Mair. 6. Glycogen Phosphorylase Isoenzyme BB; J. Mair, et al. 7. Fatty Acid-Binding Protein as a Plasma Marker for the Early Detection of Myocardial Injury; J.F.C. Glatz. 8. Mechanisms of Proteins Release from Injured Heart Muscle; W.Th. Hermens. 9. Prolonged Chest Pain and the Early Detection of Myocardial Damage by Novel Biochemical Markers - Practical Considerations; R.J. de Winter. 10. Prognostic Value of Biochemical Markers in Ischaemic Heart Disease; J. Ravkilde. 11. Troponin T in the Management of Ischaemic Heart Disease Patients; A Clinical Cardiologist's View; P. Stubbs. 12. New Soluble Markers for Assessment of Infarct Size; N. Al-Saady, A.J. Camm. 13. Value of Soluble Markers in the Diagnosis of Reperfusion after Thrombolysis; F.S. Apple. 14. The Assessment of Myocardial Damage in Heart Transplantation; J.R. Anderson. 15. Economic Aspects of New Biochemical Markers for the Detection of Myocardial Damage; P.O. Collinson. 16. Role of Serum Biochemical Markers in Clinical Trials; A.H.B. Wu. 17. Pre-Clinical Application of Markers of Myocardial Damage; D.W. Holt. Index.