Myocardial Tissue Engineering by Tatsuya ShimizuMyocardial Tissue Engineering by Tatsuya Shimizu

Myocardial Tissue Engineering

EditorTatsuya Shimizu, Katsuhisa Matsuura

Hardcover | September 2, 2015

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Regenerative therapy has rapidly developed as one of the most promising treatments for patients suffering from severe heart failure. Autologous bone marrow-derived cells and cardiac stem cells have been clinically applied for cell injection therapy for heart failure. As a next-generation therapy, tissue-engineered myocardial-patch transplantation has also been started clinically. As further advanced therapy, several researchers have started to fabricate three-dimensional beating myocardial tissues. One of the main problems in myocardial tissue engineering is neovascularization within the tissues during scale-up. Several innovative technologies have been developed to overcome the vascularization problem.

This book broadly summarizes myocardial tissue engineering and regenerative medicine, which consists of myocardial cell sources, cell therapy for damaged hearts, and tissue engineering technologies for fabricating beating hearts. With respect to myocardial cell source, it focuses on cardiac cells differentiated from embryonic stem and induced pluripotent stem cells. It describes the remarkable results obtained in the past and the present to control neovascularization and presents the future challenges in myocardial tissue engineering research.

Tatsuya Shimizuis a professor at the Institute of Advanced Biomedical Engineering and Science (ABMES), Tokyo Women's Medical University, Japan. He received his PhD in medicine from Tokyo University, Japan. His areas of expertise are myocardial tissue engineering based on cell sheet technology, neovascularization in myocardial tissue gr...
Title:Myocardial Tissue EngineeringFormat:HardcoverDimensions:252 pages, 9.02 × 5.98 × 0.98 inPublished:September 2, 2015Publisher:Taylor and FrancisLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9814411310

ISBN - 13:9789814411318

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Table of Contents


Variety of Cell Sources

Cardiomyocyte Differentiation from Stem Cells

The Technologies for Stem Cell Expansion and Differentiation

Cell Therapy for Myocardial Infarction in Clinical Trials

Scaffold-Based Tissue Engineering

Cell Sheet-Based Tissue Engineering

Scaffold-Based Myocardial Patches

Cell Sheet-Based Myocardial Patches

Scaffold-Based Myocardial Tissue Engineering

Cell Sheet-Based Myocardial Tissue Engineering

Vascularization within Engineered Myocardial Tissue

Organ-like Tissue Fabrication

Bioreactor Technologies for Myocardial Tissue Engineering

Future Developments