Nanotoxicity: Methods and Protocols by Joshua ReinekeNanotoxicity: Methods and Protocols by Joshua Reineke

Nanotoxicity: Methods and Protocols

EditorJoshua Reineke

Hardcover | September 14, 2012

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The field of nanotechnology has developed very rapidly over the past decade lending great promise to medical applications in drug delivery, therapeutics, and biological imaging. Due to the great promise, rapid development, and broad application of nanomaterials, it is imperative that researchers from development through application seek a thorough understanding of nanotoxicity.  Nanotoxicity: Methods and Protocols address the special considerations when applying toxicity studies to nanomaterials and detail newly developed methods for the study of nanotoxicity.  These diverse methods span in vitro cell culture, model tissues, in situ exposure, in vivo models, analysis in plants, and mathematical modeling, proving to be relevant to pharmaceutical scientists, material scientists, bioengineers, toxicologists, environmentalists, immunologists, and cellular and molecular biologists, to name a few.  As part of the highly successful Methods in Molecular BiologyT, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Nanotoxicity: Methods and Protocols aims to diversify the capabilities of current researchers involved in nanotoxicology and to enable researchers in related fields to expand their knowledge of how nanomaterials interface with the biological environment.
Title:Nanotoxicity: Methods and ProtocolsFormat:HardcoverDimensions:420 pagesPublished:September 14, 2012Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1627030018

ISBN - 13:9781627030014

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Table of Contents

1. Historical Overview of Nanotechnology and Nanotoxicology 2. Characterization of Nanomaterials for Toxicological Studies3. Methods for Understanding the Interaction Between Nanoparticles and Cells4. Single-Cell Gel Electrophoresis (COMET) Assay in Nano-Genotoxicology5. Single-Cell Nanotoxicity Assays of Superparamagnetic Iron Oxide Nanoparticles (SPIONs) 6. Western Blot Analysis7. Application of Reverse Transcription-PCR and Real-Time PCR in Nanotoxicity Research8. Deriving TC50 Values of Nanoparticles from Electrochemical Monitoring of Lactate Dehydrogenase (LDH) Activity Indirectly9. Enzyme-Linked Immunosorbant Assay of IL-8 Production in Response to Silver Nanoparticles10. Metabolomics Techniques in Nanotoxicology Studies11. Nanoparticle Uptake Measured by Flow Cytometry12. Determining Biological Activity of Nanoparticles as Measured by Flow Cytometry13. Whole Cell Impedance Biosensoring Devices14. Free Energy Calculation of Permeant-Membrane Interactions Using Molecular Dynamics Simulations15. Screening of Fullerene Toxicity by Haemolysis Assay16. Assessment of In Vitro Skin Irritation Potential of Nanoparticles: RHE Model17. In Vivo Methods of Nanotoxicology18. The Luminescent Bacteria Test to Determine the Acute Toxicity of Nanoparticle Suspensions19. The Primacy of Physicochemical Characterization of Nanomaterials for Reliable Toxicity Assessment: A Review of the Zebrafish Nanotoxicology Model20. Application of Embryonic and Adult Zebrafish for Nanotoxicity Assessment21. Applications of Subsurface Microscopy 22. Application of ICP-MS for the Study of Disposition and Toxicity of Metal-Based Nanomaterials 23. Quantitative Nanoparticle Organ Disposition by Gel Permeation Chromatography 24. Physiologically-Based Pharmacokinetic Modeling For Nanoparticle Toxicity Study25. Biophysical Methods for Assessing Plant Responses to Nanoparticle Exposure26. In Vivo Nanotoxicity Assays in Plant Models