Narcolepsy: Pathophysiology, Diagnosis, and Treatment by Christian R. BaumannNarcolepsy: Pathophysiology, Diagnosis, and Treatment by Christian R. Baumann

Narcolepsy: Pathophysiology, Diagnosis, and Treatment

EditorChristian R. Baumann, Claudio L. Bassetti, Thomas E. Scammell

Hardcover | July 1, 2011

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The field of narcolepsy has developed enormously within the last 10 years. Indeed the understanding of the basics of sleep-wake regulation and the discovery of new neurotransmitter systems (the hypocretins) has boosted research and key findings in the field, providing important insights into how sleep is regulated. Consequently narcolepsy now receives a great deal of attention from both clinicians and scientists throughout the world. Narcolepsy: Pathophysiology, Diagnosis, and Treatment not only offers an engaging and comprehensive treatment of a fascinating disorder but also includes a DVD that offers a unique and large collection of movies displaying the symptoms of narcolepsy in people and animals. Written by some of the best experts in the field, the book focuses on the pathophysiology of the problem and also provides critical, up-to-date insights on the key clinical issues: how to diagnose the disorder, how to treat it, and how to best manage psychosocial problems. The first and only guide to span the latest advances in narcolepsy, this reference provides sections in etiology, neurochemistry, the role of the hypocretins in sleep-wake regulation, animal models in narcolepsy, the key role of the hypothalamus, REM-sleep dysregulation, diagnosis and classification, and treatment. Compiled by an international group of more than 30 authors, Narcolepsy: Pathophysiology, Diagnosis, and Treatment is an indispensable resource for all clinicians and scientists with an interest in narcolepsy.
Christian R. Baumann, MD University Hospital of Zurich, Switzerland Claudio L. Bassetti, MD University Hospital of Zurich, Switzerland Thomas E. Scammell, MD Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
Title:Narcolepsy: Pathophysiology, Diagnosis, and TreatmentFormat:HardcoverDimensions:444 pagesPublished:July 1, 2011Publisher:Springer New YorkLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1441983899

ISBN - 13:9781441983893

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Table of Contents

1. ETIOLOGY OF NARCOLEPSYEtiology and genetics of human narcolepsyEmmanuel Mignot Narcolepsy: autoimmunity or secondary to infection?Adriano Fontana, Heidemarie Gast, Thomas  Birchler Is narcolepsy a neurodegenerative disorder?Christelle Peyron 2. NEUROCHEMISTRY OF NARCOLEPSYThe roles of hypocretin/orexin in narcolepsy, Parkinson's disease, and normal behaviourJerome Siegel Histamine in narcolepsy and excessive daytime sleepinessSeiji Nishino Dopaminergic substrates underlying hypersomnia, sleepiness, and REM sleep expressionDavid B. Rye, Amanda A.H. Freeman The serotoninergic system in sleep and narcolepsyChloé Alexandre, Thomas E. Scammell Sleep homeostasis, adenosine, caffeine, and narcolepsyHans-Peter Landolt Prostaglandin D2: an endogenous somnogenYoshihiro Urade, Osamu Hayaishi  3. THE ROLE OF THE HYPOCRETINS IN SLEEP-WAKE REGULATIONThe neurobiology of sleep-wake systems: an overviewPierre-Hervé Luppi, Patrice Fort The hypocretins/orexins: master regulators of arousal and hyperarousalMatthew E. Carter, Antoine Adamantidis, Luis de Lecea Optogenetic probing of hypocretin/orexin regulation of wakefulnessAntoine Adamantidis, Luis de Lecea Hypocretin/orexin receptor functions in mesopontine systems regulating sleep, arousal and cataplexyChristopher S. Leonard, Mike Kalogiannis, Kristi A. Kohlmeier Afferent control of the hypocretin/orexin neuronsThomas S. Kilduff, Junko Hara, Takeshi Sakurai, Xinmin Xie  The neural basis of sleepiness in narcoleptic miceThomas E. Scammell, Chloé Alexandre Mathematical models of narcolepsyCecilia Diniz Behn  4. THE KEY ROLE OF THE HYPOTHALAMUSThe hypothalamus and its functionsGiovanna Zoccoli, Roberto Amici, Alessandro Silvani  The prehistory of orexin/hypocretin and melanin-concentrating hormone neurons of the lateral hypothalamusClifford B. Saper Metabolic influence on the hypocretin/orexin neuronsDenis Burdakov Endocrine abnormalities in narcolepsyThomas Pollmächer. Marietta Keckeis, Andreas Schuld Appetite and obesityAlice Engel, Norbert Dahmen 5. REWARD, ADDICTION, EMOTIONS AND THE HYPOCRETIN SYSTEMEffects of orexin/hypocretin on ventral tegmental area dopamine neurons: an emerging role in addictionStephanie L. Borgland Orexin/hypocretin, drug addiction, and narcolepsyRalph J. DiLeone, Maysa Sarhan, Ruth Sharf Emotional processing in narcolepsySophie Schwartz Depression in narcolepsyMichael Lutter 6. REM SLEEP DYSREGULATION AND MOTOR ABNORMALITIES IN NARCOLEPSYThe clinical features of cataplexySebastiaan Overeem Parasomnias in narcolepsy with cataplexyYves Dauvilliers, Régis Lopez The motor system and narcolepsy: Periodic leg movements and restless leg syndromeLuigi Ferini Strambi  7. THE BORDERLANDS OF NARCOLEPSYSpectrum of narcolepsyClaudio Bassetti Secondary narcolepsyPhilipp O. Valko, Rositsa Poryazova Posttraumatic narcolepsyChristian R. Baumann, Rositsa PoryazovaThe hypocretin/orexin system and sleepiness in Parkinson's diseaseRolf Fronczek Idiopathic hypersomniaRamin Khatami 8. THE DIAGNOSIS OF NARCOLEPSY AND THE ASSESSMENT OF FITNESS TO DRIVECurrent diagnostic criteria of adult narcolepsyAlex Iranzo The arguments for standardized diagnostic proceduresGeert Mayer Fitness to drive in narcolepsyJohannes Mathis 9. TREATMENT OF NARCOLEPSYTreatment of narcolepsyGert Jan Lammers Treatment of narcolepsy in the childMichel Lecendreux

Editorial Reviews

From the reviews:"This comprehensive review of narcolepsy, written by scientific experts in the field of sleep disorders research and medicine, serves as guide to understanding its etiology, pathophysiology, and clinic treatment. . It is targeted primarily for sleep researchers and clinicians, as well as those who have a specific interest in narcolepsy. . With its in-depth analysis of the important areas of the etiology, diagnosis, prognosis, treatment, and management of narcolepsy, this is a useful compendium for both scientists and clinicians." (Maureen A. Smith, Doody's Review Service, January, 2012)