National Institute of Allergy and Infectious Diseases, NIH: Volume 1: Frontiers in Research by Vassil St. GeorgievNational Institute of Allergy and Infectious Diseases, NIH: Volume 1: Frontiers in Research by Vassil St. Georgiev

National Institute of Allergy and Infectious Diseases, NIH: Volume 1: Frontiers in Research

EditorVassil St. Georgiev, Karl Western, John J. McGowan

Paperback | November 19, 2010

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For over 50 years, the mission of the National Institute of Allergy and Infectious Diseases (NIAID) has been to conduct and support basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases with the ultimate goal of improving the health of individuals in the United States and around the world. As part of its mission to foster biomedical discovery and to reduce the burden of human disease, NIAID is committed to encouraging the accelerated translation of biomedical discoveries into effective clinical care and public health practice throughout the world. In pursuit of this goal and its disease-specific scientific objectives, NIAID seeks to broaden research opportunities and collaborations involving scientists and institutions outside the United States. National Institute of Allergy and Infectious Diseases, NIH: Volume 1, Frontiers in Research contains presentations given at the 2006 NIAID Research Conference held in Opatija, Croatia which brought internationally known researchers from the United States and Central and Eastern Europe to focus together on shared interests in microbiology, infectious disease, HIV/AIDS, and basic and clinical immunology. Some of the topics covered include emerging and re-emerging infections, the development of infectious disease prophylactics and therapeutics, drug resistance, and various topics in immunomodulation, autoimmunity, infections and immunity, and the development of vaccines. Extensive and in-depth, National Institute of Allergy and Infectious Diseases, NIH: Volume 1, Frontiers in Research is a valuable, comprehensive guide to the state of research today.
Title:National Institute of Allergy and Infectious Diseases, NIH: Volume 1: Frontiers in ResearchFormat:PaperbackDimensions:548 pages, 10.98 × 8.27 × 0.01 inPublished:November 19, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617379441

ISBN - 13:9781617379444

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Table of Contents

Dedication Acknowledgments Preface Vassil St. Georgiev Contributors Part I. Introduction0. National Institute of Allergy and Infectious Diseases (NIAID): An OverviewKarl A. Western Part II. Microbiology and Infectious DiseasesSection 1.Emerging and Re-Emerging Infections 1 Biotools for Determining the Genetics of Susceptibility to Infectious Diseases and Expediting Research Translation into Effective CountermeasuresMalak Kotb, Robert W. Williams, Nourtan Fathey, Mohamed Nooh, Sarah Rowe, Rita Kansal, and Ramy Aziz 2 Spore Surface Components and Protective Immunity to Bacillus anthracis Patricia Sylvestre, Ian Justin Glomski, Evelyne Couture-Tosi, Pierre Louis Goossens, and Michèle Mock  3 New Candidate Anthrax Pathogenic FactorsSerguei G. Popov 4 Ehrlichiae and Ehrlichioses: Pathogenesis and Vector BiologyH. L. Stevenson, N. Ismail, and D.H. Walker5 Multiple Locus Variable Number Tandem Repeat (VNTR) Analysis (MLVA) of Brucella spp. Identifies Species-Specific Markers and Insights into Phylogenetic RelationshipsLynn Y. Huynh, Matthew N. Van Ert, Ted Hadfield, William S. Probert, Bryan H. Bellaire, Michael Dobson, Robert J. Burgess, Robbin S. Weyant, Tanja Popovic, Shaylan Zanecki, David M. Wagner, and Paul Keim 6 Expression of the MtrC-MtrD-MtrE Efflux Pump in Neisseria gonorrhoeae and Bacterial Survival in the Presence of AntimicrobialsWilliam M. Shafer, Jason P. Folster, Douglas E. Warner, Paul J. T. Johnson, Jennifer Rocco, Jacqueline. T. Balthazar, Nazia Kamal, and Ann E. Jerse Section 2.Tuberculosis 7 What can Mycobacteriophages Tell Us About Mycobacterium tuberculosis?Graham F. Hatfull 8 Clinical Mycobacterium tuberculosis Strains Differ in their Intracellular Growth in Human MacrophagesSue A. Theus, M. Donald Cave, Kathleen D. Eisenach  9 Mechanisms of Latent Tuberculosis: Dormancy and Resuscitation of M. tuberculosisGalina Mukamolova, Elena Salina, and Arseny Kaprelyants 10 Separating Latent and Acute Disease in the Diagnosis of Tuberculosis T. Mark Doherty  11 Mutant Selection Window Hypothesis: A Framework for Anti-Mutant Dosing of Antimicrobial AgentsKarl Drlica and Xilin Zhao Section 3.Avian Influenza12 The NIAID Influenza Genome Sequencing ProjectLone Simonsen, Gayle Bernabe, Karen Lacourciere, Robert J. Taylor, and Maria Y. Giovanni 13 Lessons from the 1918 Spanish Flu Epidemic in IcelandMagnús Gottfredsson14 Control of Notifiable Avian Influenza Infections in Poultry Ilaria Capua and Stefano Marangon 15 Understanding the Complex Pathobiology of High Pathogenicity Avian Influenza Viruses in BirdsDavid E. SwayneSection 4.Prophylactics and Therapeutics for Infectious Diseases16 Development of Prophylactics and Therapeutics against the Smallpox and Monkeypox Biothreat AgentsMark Buller, Lauren Handley, and Scott Parker17 The Hierarchic Informational Technology for QSAR Investigations. Molecular Design of Antiviral Compounds.V. E. Kuz'min, A. G. Artemenko, E. N. Muratov, L. N. Ognichenko, A. I. Hromov, A.V. Liahovskij, and P.G. Polischuk 18 Antivirals for Influenza: Novel Agents and ApproachesWilliam A Fischer II, and Frederick Hayden 19 Anti-Infectious Actions of the Proteolysis Inhibitor e-Aminocaproic Acid (E-ACA)V. P. Lozitsky20 A New Highly Potent Antienteroviral CompoundLubomira Nikolaeva-Glomb, Stefan Philipov, and Angel S. Galabov Section 5.Russian Perspectives in Emerging and Re-Emerging Infections Research21 Reduction and Possible Mechanisms of Evolution of the Bacterial GenomesGeorge B. Smirnov 22 Interaction of Yersinia pestis Virulence Factors with IL-1R/TLR Recognition SystemVyacheslav M. Abramov, Valentin S. Khlebnikov, Anatoly M. Vasiliev, Igor V. Kosarev, Raisa N. Vasilenko, Nataly L. Kulikova, Vladimir L. Motin, Georgy B. Smirnov, Valentin I. Evstigneev, Nicolay N. Karkischenko, Vladimir N. Uversky, and Robert R. Brubaker 23 IS481-Induced Variability of Bordetella pertussisLudmila N. Sinyashina, Alisa Yu. Medkova, Evgeniy G. Semin, Alexander V. Chestkov, Yuriy D. Tsygankov, and Gennagiy I. Karataev 24 Microarray Immunophosphorescence Technology for the Detection of Infectious PathogensNikolay S. Osin and Vera G. Pomelova25 Development of Immunodiagnostic Kits and Vaccines for Bacterial InfectionsValentina A. Feodorova and Onega V. Ulianova Section 6.Perspectives in Emerging and Re-Emerging Infections - Research inCentral Asia and Caucases 26 Research in Emerging and Re-Emerging Diseases in Central Asia and the Caucasus: Contributions by the the National Institute of Allergy and Infectious Diseases, NIHKatherine T. Herz 27 Disease Surveillance in Georgia: Benefits of International CooperationLela Bakanidze, Paata Imnadze, Shota Tsanava, and Nikoloz Tsertsvadze 28 Epidemiology (Including Molecular Epidemiology) of HIV, Hepatitis B and C in Georgia: Experience from US-Georgian CollaborationTengiz Tsertsvadze 29 The National Tuberculosis Program in the Republic of Georgia:An OverviewArchil Salakaia, Veriko Mirtskhulava, Shalva Gamtsemlidze, Marina Janjgava, Rusudan Aspindzelashvili,and Ucha Nanava Part III. Human Immunodeficiency Virus and AIDS30 Virus Receptor Wars: Entry Molecules Used For and Against Viruses Associated with AIDSEdward A. Berger 31 HIV Latency and Reactivation: The Early Years.Guido Poli 32 HIV-1 Sequence Diversity as A Window into HIV-1 BiologyMilloni Patel, Gretja Schnell, and Ronald Swanstrom  33 Human Monoclonal Antibodies against HIV and Emerging VirusesDimiter S. Dimitrov 34 Biological Basis and Clinical Significance of HIV Resistance to Antiviral DrugsMark A. Wainberg and Susan Schader 35 NIAID HIV/AIDS Prevention Research David N. Burns and Roberta Black 36 Epidemiological Surveillance of HIV and AIDS in LithuaniaSaulius Caplinskas  Part IV. Immunology and vaccinesSection 1.Immunomodulation37 TACI, Isotype Switching, CVID and IgAD Emanuela Castigli and Raif S. Geha 38 A Tapestry of Immunotherapeutic Fusion Proteins: From Signal Conversion to Auto-StimulationMark L. Tykocinski, Jui-Han Huang, and Michal Dranitzky-Elhalelbbi39 A Role for Complement System in Mobilization and Homing of Hematopoietic Stem/Progenitor CellsR. Reca, M. Wysoczynski, M. Kucia, J. Ratajczak, and M. Z.ajczak40 Post-Translational Processing of Human Interferon-y Produced in Escherichia coli and Approaches for Its PreventionMaya Boyanova, Roumyana Mironova, Toshimitsu Niwa, and Ivan G. Ivanov Section 2.Autoimmunity41 B-Cell Dysfunctions in Autoimmune DiseasesMoncef Zouali 42 A Model System for Studying Mechanisms of B-Cell Transformation In Systemic AutoimmunityWendy F. Davidson, Partha Mukhopadhyay, Mark S. Williams, Zohreh Naghashfar, Jeff X. Zhou, and Herbert C. Morse III 43 Breach and Restoration of B-Cell Tolerance in Human Systemic Lupus Erythematosus (SLE)Iñaki Sanz, R. John Looney, and J. H. Anolik Section 3.Infection and Immunity44 Dendritic Cells: Biological and Pathological AspectsJacques Banchereau, John Connolly, Tiziana Di Pucchio, Carson Harrod, Eynav Klechevsky, A. Karolina Palucka, Virginia Pascual, and Hideki Ueno 45 Immunomic and Bioinformatics Analysis of Host Immunity in the Vaccinia Virus and Influenza A SystemsMagdalini Moutaftsi, Bjoern Peters, Valerie Pasquetto, Carla Oseroff, John Sidney, Huynh Hoa-Bui, Howard Grey, and Alessandro Sette  46 Immunoreaction to HantavirusesAlemka Markotic and Connie Schmaljohn 47 Innate Immunity to Mouse CytomegalovirusDurdica Cekinovic, Irena Slavuljica, Tihana Lenac, Astrid Krmpotic, Bojan Polic and Stipan Jonjic Section 4.Vaccines48 Research and Development of Chimeric Flavivirus VaccinesSimon Delagrave, and Farshad Guirakhoo 49 Correlates of Immunity Elicited by Live Yersinia pestis VaccineVivian L. Braciale, Michael Nash, Namita Sinha, Irina V. Zudina, and Vladimir L. Motin Part V. Building A Sustainable PERSONAL Research Portfolio50 Strategies for a Competitive Research CareerHortencia Hornbeak and Peter R. Jackson51 Selecting the Appropriate Funding MechanismPriti Mehrotra, Hortencia Hornbeak, Peter R. Jackson, and Eugene Baizman52 Preparing and Submitting a Competitive Grant ApplicationPeter R. Jackson and Hortencia Hornbeak53 Identifying Research Resources and Funding Opportunities Eugene Baizman, Hortencia Hornbeak, Peter R. Jackson, and Priti Mehrotra

Editorial Reviews

From the reviews:"This introduction to the structure, activities, and mission of the NIAID includes a section on building a sustainable research career. . The book is intended for students and early career biomedical researchers . . Useful introductory and career planning sections help readers understand the NIH and the grant writing process." (Kari A. Simonsen, Doody's Review Services, January, 2009)