Natural Products: Drug Discovery and Therapeutic Medicine by Lixin ZhangNatural Products: Drug Discovery and Therapeutic Medicine by Lixin Zhang

Natural Products: Drug Discovery and Therapeutic Medicine

EditorLixin Zhang, Arnold L. Demain

Paperback | November 5, 2010

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A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
Title:Natural Products: Drug Discovery and Therapeutic MedicineFormat:PaperbackDimensions:400 pages, 10 × 7.01 × 0.01 inPublished:November 5, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617375330

ISBN - 13:9781617375330

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Table of Contents

Part I. Fundamental Issues Related to Natural Product-Based Drug DeliveryNatural Products and Drug DiscoveryArnold L. Demain and Lixin ZhangPart II. StrategiesIntegrated Approaches for Discovering Novel Drugs From Microbial Natural ProductsLixin ZhangAutomated Analyses of HPLC Profiles of Microbial Extracts: A New Tool for Drug Discovery ScreeningJosé R. Tormo and Juan B. GarcíaManipulating Microbial Metabolites for Drug Discovery and ProductionC. Richard HutchinsonImproving Drug Discovery From MicroorganismsChris M. Farnet and Emmanuel ZazopoulosDevelopments in Strain Improvement Technology: Evolutionary Engineering of Industrial Microorganisms Through Gene, Pathway, and Genome ShufflingStephen B. del CardayréPart III. Specific Groups of DrugsThe Discovery of Anticancer Drugs From Natural SourcesDavid J. Newman and Gordon M. CraggCase Studies in Natural-Product Optimization: Novel Antitumor Agents Derived From Taxus brevifolia and Catharanthus roseusJian Hong and Shu-Hui ChenTerpenoids As Therapeutic Drugs and Pharmaceutical AgentsGuangyi Wang, Weiping Tang, and Robert R. BidigareChallenges and Opportunities in the Chinese Herbal Drug IndustryWei Jia and Lixin ZhangArsenic Trioxide and Leukemia: From Bedside to BenchGuo-Qiang Chen, Qiong Wang, Hua Yan, and Zhu ChenPart IV. Microbial DiversityNew Methods to Access Microbial Diversity for Small Molecule DiscoveryKarsten Zengler, Ashish Paradkar, and Martin KellerAccessing the Genomes of Uncultivated Microbes for Novel Natural ProductsAsuncion Martinez, Joern Hopke, Ian A. MacNeil, and Marcia S. OsburnePart V. Specific SourcesNew Natural-Product Diversity From Marine ActinomycetesPaul R. Jensen and William FenicalNovel Natural Products From Rainforest EndophytesGary Strobel, Bryn Daisy, and Uvidelio CastilloBiological, Economic, Ecological, and Legal Aspects of Harvesting Traditional Medicine in EcuadorAlexandra Guevara-Aguirre and Ximena ChiribogaIndex

Editorial Reviews

From the reviews:"Natural Products, Drug Discovery and Therapeutic Medicine timely shares the experience of renowned scientist from academy and industry working in the field. . a very comprehensive tool that will help everybody interested in the discovery of natural products. I highly recommend this book for those who want to understand the potential of drug development from natural products in the light of modern knowledge and technology as well as for individuals who want to understand history of pass successes in drug discovery from natural products." (Sonia Mesia-Vela, Phytomedicine, Vol. 13, 2006)