Negative Co-Receptors and Ligands by Rafi AhmedNegative Co-Receptors and Ligands by Rafi Ahmed

Negative Co-Receptors and Ligands

EditorRafi Ahmed, Tasuku Honjo

Paperback | May 29, 2013

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Adaptive immune responses serve as a key defense mechanism for the control of infections in vertebrates. Immune responses must be of sufficient strength to contain invading pathogens, antigen specific responses require regulatory mechanisms to ensure termination or downmodulation to avoid excessive damage to the host tissue. For both branches of the adaptive immune system, regulatory molecules i.e. coreceptors and ligands have been identified that control the signaling cascades initiated by engagement of the T cell and B cell antigen receptors. This book describes biological functions as well as molecular mechanisms of these molecules.
Title:Negative Co-Receptors and LigandsFormat:PaperbackDimensions:160 pages, 9.25 × 6.1 × 0 inPublished:May 29, 2013Publisher:Springer Berlin HeidelbergLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3642267777

ISBN - 13:9783642267772

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Table of Contents

Preface.- TIM-3 and its regulatory role in immune responses.- The role of PD-1 in regulating T cell immunity.- The role of IL-10 in regulating immunity to persistent viral infections. -Inhibitory Ly49 receptors on mouse Natural Killer cells.-Immunoregulatory roles for Fc receptor-like molecules.- Fcgamma Rs in health and disease.- TGF-beta function in immune suppression.- Subject index