Neonatal Immunity by Constantin BonaNeonatal Immunity by Constantin Bona

Neonatal Immunity

byConstantin Bona

Paperback | November 9, 2010

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A critical review of the classic, as wells as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants. Dr. Bona shows how the antibody response of neonates is modulated by maternal antibodies and how, in certain cases, this can cause transient or life-threatening neonatal autoimmune disease. He also describes the characteristics of neonatal tolerance induced by foreign allo- and self-antigens, which are the basis for understanding impaired infant immune response and which provide a rationale for the development of efficient neonatal vaccines. By making clear the characteristics and differences between the immune system and the immune responses of both newborns and infants, compared to those of adults, Dr. Bona offers insights and challenging hypotheses that promise to help overcome the poor responses of neonates to various antigens.
Title:Neonatal ImmunityFormat:PaperbackDimensions:389 pages, 22.9 × 15.2 × 0.07 inPublished:November 9, 2010Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:161737492X

ISBN - 13:9781617374920

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Table of Contents

Structure and Function of the Immune System in VertebratesOntogeny and the Development of Cells Mediating Innate and Adaptive ImmunityPhenotypic Characteristics of Neonatal B CellsMolecular Characteristics of Neonatal B-Cell RepertoireGenetically Programmed Temporal Ordered Activation of Neonatal B-Cell ClonesAntibody Response in Fetuses and NewbornsEffect of Maternal Antibodies on Neonatal B-Cell ResponseNeonatal Autoimmune Diseases Caused by Maternal Pathogenic AutoantibodiesPhenotypic Characteristics of Neonatal T CellsExpression of MHC Molecules in Neonates. Neonatal Cytokine NetworkCell-Mediated Immune Responses in Neonates. Fetal and Neonatal ToleranceDevelopment of Efficient Prophylactic Vaccines and Theracines for Newborns and InfantsReferencesIndex.

Editorial Reviews

" excellent reference reference for both reviewing the existing literature and for updating our current knowledge and understanding of how the immune system develops during foetal and neonatal life. This text is by far the most comprehensive review to date on neonatal immunity and I strongly recommend it to anyone with interest in the field." -Australian Veterinary Journal" excellent source of both old and cutting-edge information on neonatal immunity." - New England Journal of Medicine