Nerve Repair by Thomas M. Brushart

Nerve Repair

byThomas M. Brushart

Hardcover | June 19, 2011

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Peripheral nerves are biologic wires that convey the desire for motion from brain to muscle, and the experience of touch from skin to brain. When a nerve is cut, the individual fibers, or axons, must regenerate from the site of injury to reconnect with their skin and muscle targets. Nerveregeneration is a process of bewildering complexity that requires the coordinated action of multiple biologic systems. Gene expression within the neuron is altered to support axon growth, regenerating axons must cross the complex environment of the nerve injury and enter pathways that lead tofunctionally appropriate end organs, Wallerian degeneration clears these pathways of axon debris, and Schwann cells in the distal nerve must produce growth factors to support regeneration. In spite of this complexity, the surgical repair of transected nerve remains a mechanical process that haschanged little in the last century, and that restores normal function to only 10% of adults with nerve injuries.Improving the outcome of nerve repair will require close cooperation between surgeon and scientist. Skyrocketing clinical demands on the surgeon and the rapidly increasing sophistication of neuroscience have interacted to form two distinct cultures. Nerve Repair bridges these cultures by providing atranslational review of the clinical and basic science relevant to nerve repair. It provides the clinician with an understanding of pertinent research, and the basic scientist with an overview of the clinical manifestations of nerve injury and regeneration. It is also grounded in the history ofperipheral nerve surgery and biology so that modern concepts can be understood in the context of their origins.

About The Author

Dr. Thomas Brushart, MD, received his undergraduate and medical training at Harvard University. For over 25 years he has cared for patients with hand and peripheral nerve injuries while maintaining a research program in peripheral nerve regeneration. This synergy has culminated in the writing of Nerve Repair, a translational work that...

Details & Specs

Title:Nerve RepairFormat:HardcoverDimensions:480 pages, 10 × 7 × 0.98 inPublished:June 19, 2011Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195169905

ISBN - 13:9780195169904

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Table of Contents

ForewordPreface1. Peripheral Nerve Anatomy and Function2. Touch3. Motion4. Determining Clinical Outcomes5. Clinical Nerve Repair and Grafting6. Determining Experimental Outcome7. Outcomes of Experimental Nerve Repair and Grafting8. The Nerve Gap- Beyond Autograft9. Nerve Regeneration10. Specificity in Nerve Regeneration11. Systems of Organization after Nerve Repair or Transfer12. Treatment Strategies