Neural Stem Cells for Brain and Spinal Cord Repair by Tanja ZigovaNeural Stem Cells for Brain and Spinal Cord Repair by Tanja Zigova

Neural Stem Cells for Brain and Spinal Cord Repair

EditorTanja Zigova

Paperback | November 19, 2010

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Active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division and differentiation, and defines the methods of NSC expansion and propagation, neuromorphogenesis, the factors determining cell fate both in vitro and in situ, and the induction of self-reparative processes within the brain. They also present strategies that may lead to fruitful clinical applications in the near future. These range from the replacement of degenerated, dysfunctional, or maldeveloped cells to the provision of factors that may protect, correct, recruit, promote self-repair, or mediate the connectivity of host cells.
Title:Neural Stem Cells for Brain and Spinal Cord RepairFormat:PaperbackDimensions:453 pagesPublished:November 19, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617372986

ISBN - 13:9781617372988

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Table of Contents

Part I. Stem Cells for and from the CNS: Their Source and Fundamental PropertiesSources of Cells for CNS TherapyMelissa K. Carpenter, Mark Mattson, and Mahendra S. RaoNeural Stem Cells and Their PlasticityAngela Gritti, Angelo Vescovi, and Rossella GalliIdentification, Selection, and Use of Adult Human Oligodendrocyte Progenitor CellsMartha Windrem, Neeta Roy, Marta Nunes, and Steven A. GoldmanGeneration, Characterization, and Transplantation of Immortalized Human Neural Crest Stem CellsEiji Nakagawa, Kozo Hatori, Atsushi Nagai, Hyun B. Choi, Myung A. Lee, Jung H. Bang, Jean Kim, Jae K. Ryu, Akihiko Ozaki, Min C. Lee, Evan Y. Snyder, and Seung U. KimThe Search for Neural Progenitors in Bone Marrow and Umbilical Cord BloodShijie Song, Paul Sanberg, and Juan Sanchez-RamosPart II. In Vitro and/or In Vivo Manipulations of Stem/Progenitor Cells for the CNSSignal Transduction Pathways That Regulate Neural Stem Cell Division and DifferentiationLuciano Conti and Elena CattaneoNeural Stem/Progenitor Cell Clones or "Neurospheres": A Model for Understanding NeuromorphogenesisDennis A. Steindler, Bjorn Scheffler, Eric D. Laywell, Oleg N. Suslov, Tong Zheng, Thomas Reiniger, and Valery G. KukekovNeural Stem Cells and Specification of Cell Fates: Biological and Therapeutical PerspectivesMarcel M. DaadiManipulation of Neural Precursors In Situ: Potential for Brain Self-RepairSanjay S. P. Magavi and Jeffrey D. MacklisNeural Stem Cells in the Adult HippocampusJasodhara Ray and Daniel A. PetersonPart III. Stem/Progenitor Cells in Representative Therapeutic Paradigms for the CNSGlobal Gene and Cell Replacement Strategies via Stem CellsKook In Park, James J. Palacino, Roseanne Taylor, Karen S. Aboody, Barbara A. Tate, Vaclav Ourednik, Jitka Ourednik, Mahesh Lachyankar, and Evan Y. SnyderNeural Stem Cells in and from the Spinal Cord, Yang D. Teng, Mary Katherine C. White, Erin Lavik, Shaoxiang Liu, Mahesh Lachyankar, Kook In Park, and Evan Y. SnyderStem Cells for Spinal Cord Injury, Paul Lu, Evan Y. Snyder, and Mark H. TuszynskiSpinal Ischemia-Induced Paraplegia: A Potential Therapeutical Role of Spinally Grafted Neural Precursors and Human hNT NeuronsMartin Marsala, Osamu Kakinohana, Tony L. Yaksh, and Joho TokumineUtilization of Marrow Stromal Cells for Gene Transfer into the CNSS. Ausim Azizi, Emily J. Schwarz, Darwin Prockop, Guillermo Alexander, Katherine A. Mortati, and Barbara KrynskaPreclinical Basis for Use of NT2N Cells in Neural Transplantation TherapyCesario V. Borlongan and Paul R. SanbergIndex

Editorial Reviews

"The purpose is to address research protocols and possible future applications of neural stem cells in clinical practice. The author has met the objectives. . .Starting from the basic aspects of cell culturing, this book emphasizes the different available research protocols that are currently being used for possible management of neurological degenerative diseases. In addition, molecular mechanisms of interaction are always explained whenever necessary. This book is a perfect purchase for neurologists and neuroscientists. Neurosurgeons with a basic science interest would also find this a useful acquisition."-Doody's Health Sciences Book Review Journal