Neuro-immuno-gastroenterology by Cris S. ConstantinescuNeuro-immuno-gastroenterology by Cris S. Constantinescu


byCris S. ConstantinescuEditorRäzvan I. Arsenescu, Violeta Arsenescu

Hardcover | June 2, 2016

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This book addresses important issues regarding the interaction between the nervous system, the immune system, and the digestive system. Gut flora has a profound influence on the shaping of the immune response, not only in the gastrointestinal system but also in the nervous system. Fascinatingly, manipulation of intestinal immune responses can be used to modulate neurological disease. Conversely, the nervous system and the psyche have significant effects on the functioning of the gut and liver. 

After introductory chapters on the neurology, the immunology and microbiology of the gut, the effects of the gut immune system and gut flora and its manipulation on neurological disease are discussed, followed by molecular mimicry and immune tolerance in neuroimmune diseases. Additionally, several chapters deal with gastrointestinal manifestations of neurological diseases. 

Neuro-Immuno-Gastroenterologyis aimed at neurologists, gastroenterologists, and immunologists.

Cris S Constantinescu graduated from Boston University School of Medicine and completed a PhD in Immunology at the University of Pennsylvania. He completed training in Neurology and Fellowship in Neuroimmunology at the University of Pennsylvania. His main research interest is in the immunopathogenesis and the immunotherapeutics of mult...
Title:Neuro-immuno-gastroenterologyFormat:HardcoverDimensions:337 pagesPublished:June 2, 2016Publisher:Springer NatureLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3319286072

ISBN - 13:9783319286075


Table of Contents

The immunology of the gastrointestinal system.- The enteric nervous system.- Microbial regulation of gastrointestinal immunity in health and disease.- Roles of substance P in gastrointestinal functions and neuroimmune interactions.- Immunomodulation by vasoactive intestinal polypeptide (VIP).-Helicobacter pylori, experimental autoimmune encephalomyelitis, and multiple sclerosis.- Stress and the gastrointestinal system.- Nutrition, macrobiotics and the brain neuroinflammatory response.- Guillain-Barré syndrome andCampylobacter jejunienteritis.- Gut microbiota: a possible role in the pathogenesis of multiple sclerosis.- Intestinal parasites and immunomodulation in neuroinflammatory disease.- Neurological complications of anti-TNF treatments and other neurological aspects of inflammatory bowel disease.- Intestinal bacterial antigens, toxin-induced pathogenesis and immune cross-reactivity in neuromyelitis optica and multiple sclerosis.- Targeting immunomodulatory agents to the gut-associated lymphoid tissue.- The neuroimmunology of gluten intolerance.- The neurology of autoimmune pernicious anaemia (subacute combined degeneration).- The impact of multiple sclerosis on gastrointestinal system function.- The neurology of Whipple's disease.

Editorial Reviews

"This book is designed to increase the understanding of the complex relationship between the gut flora, the nervous system, and the immune system, a topic that is often poorly understood and underappreciated in clinical medicine. . book is intended for practicing clinicians in the fields of gastroenterology, neurology, and immunology, written by authors who are experts in their fields. . a useful contribution to the field, as many books aiming to cover a wealth of information lack these specific topics." (Nicole E. Pisapia, Doody's Book Reviews, March, 2017)