Neuroanatomy and Pathology of Sporadic Parkinson's Disease by Heiko BraakNeuroanatomy and Pathology of Sporadic Parkinson's Disease by Heiko Braak

Neuroanatomy and Pathology of Sporadic Parkinson's Disease

byHeiko Braak, Kelly Del Tredici

Paperback | December 3, 2008

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The synucleinopathy sporadic Parkinson's disease (sPD) is the second most frequent degenerative disorder of the human nervous system after Alzheimer's disease. The propensity for developing sPD exists in all ethnic groups worldwide, and the prevalence of the disorder increases considerably with age, thereby imposing an enormous social and economic burden on societies with increased life expectancy. The sPD-associated pathological process is progressive, does not go into remission, and can take decades to reach its culmination if it is not be terminated prematurely by death owing to other causes.

Against the background of the normal morphology and anatomy, the authors analyze the pathoanatomy of sPD in the nervous system at various neuropathological stages and summarize the potential functional consequences of the lesions.

Title:Neuroanatomy and Pathology of Sporadic Parkinson's DiseaseFormat:PaperbackDimensions:119 pagesPublished:December 3, 2008Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3540798498

ISBN - 13:9783540798491

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Table of Contents

Prologue.- Morphology of Lewy Pathology.- The Evolving Distribution Pattern of Lewy Pathology Associated with sPD Renders Neuropathological Staging Possible.- Stage 1.- Stage 2.- Stage 3.- Stage 4.- Stages 5 and 6.- The Progression of the Cortical Lesions Mimics the Pattern of Myelination in Reverse Order.- The Staging Hypothesis: Assumptions, Challenges, Potential.