Neurobiology of Alzheimers Disease

Hardcover | May 9, 2007

EditorDavid Dawbarn, Shelley J. Allen

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Alzheimer's disease is the most common form of dementia in the elderly; 450,000 people in the UK and 4.5 million people in the USA suffer with this disease. This 3rd edition of 'Neurobiology of Alzheimer's Disease' gives a comprehensive and readable introduction to the disease, from molecularpathology to clinical practice. The book is intended for readers new to the field, and it also covers an extensive range of themes for those with in-depth knowledge of Alzheimer's disease. It will therefore act either as an introduction to the whole field of neurodegeneration or it will help experienced researchers to access thelatest research in specialist topics. Each chapter is written by eminent scientists leading their fields in neuropathology, clinical practice and molecular neurobiology; appendices detail disease-associated proteins, their sequences, familial mutations and known structures. It will be essential reading for students interested in neurodegeneration and for researchers and clinicians, giving a coherent and cohesive approach to the whole area of research, and allowing access at different levels. For those in the pharmaceutical industry it describes the underlyingmolecular mechanisms involved in the pathogenesis of Alzheimer's disease and explains how current and potential therapeutics may work.

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From the Publisher

Alzheimer's disease is the most common form of dementia in the elderly; 450,000 people in the UK and 4.5 million people in the USA suffer with this disease. This 3rd edition of 'Neurobiology of Alzheimer's Disease' gives a comprehensive and readable introduction to the disease, from molecularpathology to clinical practice. The book i...

David Dawbarn obtained his PhD from the University of Bristol and then initiated his work on Alzheimer's disease (AD) at the Medical Research laboratories in Cambridge as a Research Fellow. He returned to Bristol to take up a lectureship investigating the molecular pathology of Alzheimer's disease and developing new therapies. His int...
Format:HardcoverDimensions:488 pages, 9.69 × 6.73 × 1.22 inPublished:May 9, 2007Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198566611

ISBN - 13:9780198566618

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Table of Contents

1. Shelley J Allen: Alzheimer's disease: a hundred years of investigation2. Margaret M Esiri: The neuropathology of Alzheimer's disease3. Alison M Goate: Molecular genetics of Alzheimer's disease4. Edward B Lee and Virginia M-Y Lee: Biology and molecular neuropathology of beta-amyloid protein5. Khalid Iqbal, Alejandra del C Alonso, M Omar Chohan, Ezzat El-Akkad, Cheng-Xin Gong, Sabiha Khatoon, Fei Liu and Inge Grundke-Iqbal: The molecular basis of tau protein pathology: role of abnormal hyperphosphorylation6. Agueda Rostagno, Ratnesh Lal and Jorge Ghiso: Protein misfolding, aggregation and fibril formation: common features of cerebral and non-cerebral amyloidosis7. Suzanne E Wahrle and David M Holtzman: Apolipoprotein E, amyloid beta-peptide and Alzheimer's disease8. Kulandaivelu S Vetrivel and Gopal Thinakaran: Presenilins9. Dick Terwel, Ilse Dewachter, Tom van Dooren, Tom Vandebroek, Thomas Van Helmont, David Muyllaert, Peter Borghgraef, Sophie Croes, Joris Winderickx and Fred van Leuven: Multiple transgenic mouse models for Alzheimer's disease10. Mark P Mattson: Inflammation and Alzheimer's disease11. Xi Chen, David Stern and Shi Du Yan: Cellular targets of amyloid beta-peptide: potential roles in neuronal cell stress and toxicity12. Mitchell K P Lai, Maria J Ramirez, Shirley W Y Tsang and Paul T Francis: Alzheimer's disease as a neurotransmitter disease13. Elliott J Mufson, Scott E Counts, Margaret Fahnestock and Stephen D Ginsberg: NGF family of neurotrophins and their receptors: early involvement in the progression of Alzheimer's disease14. Sarmishtha Bhattacharyya, Ros Overshott and Alistair Burns: Clinical assessment of Alzheimer's disease15. Henrik Zetterburg and Kaj Blennow: Molecular and biological markers for Alzheimer's disease16. Gordon K Wilcock and David Dawbarn: Current pharmacological approaches to treating Alzheimer's disease17. Weiming Xia: Amyloid-based therapies18. Colin L Masters: Future directions: the A-beta amyloid pathway as the target for diagnosing, preventing or treating Alzheimer's disease

Editorial Reviews

`This book will appeal to the broad readership that it is intended for including researchers and clinicians.'International Journal of Geriatric Psychiatry