Neurobiology of Mental Illness

Paperback | May 8, 2011

EditorDennis S. Charney, Eric J. Nestler

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This is a new edition of the first comprehensive text to show how the advances in molecular and cellular biology and in the basic neurosciences have brought the revolution in molecular medicine to the field of psychiatry. The book begins with a review of basic neuroscience and methods forstudying neurobiology in human patients then proceeds to discussions of all major psychiatric syndromes with respect to knowledge of their etiology, pathophysiology, and treatment. Emphasis is placed on synthesizing information across numerous levels of analysis, including molecular biology andgenetics, cellular physiology, neuroanatomy, neuropharmacology, and behavior, and in translating information from the basic laboratory to the clinical laboratory and finally to clinical treatment. Editors Dennis Charney and Eric Nestle, along with their six section editors and over 150 contributors, have revised and updated all 80 chapters from the previous edition and have added new chapters on topics relating to, for example, genetics, experimental therapeutics, and late-life mooddisorders. Both a textbook and a reference book, Neurobiology of Mental Illness is intended for psychiatrists, neuroscientists, and their students or trainees.

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This is a new edition of the first comprehensive text to show how the advances in molecular and cellular biology and in the basic neurosciences have brought the revolution in molecular medicine to the field of psychiatry. The book begins with a review of basic neuroscience and methods forstudying neurobiology in human patients then pr...

Dennis S. Charney, MD, is Dean at Mount Sinai School of Medicine, Executive Vice President for Academic Affairs, The Mount Sinai Medical Center, and Anne and Joel Ehrenkranz Professor in the Departments of Psychiatry, Neuroscience, and Pharmacology and Systems Therapeutics at Mount Sinai School of Medicine in New York, NY. Eric J. Nest...

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Format:PaperbackDimensions:1504 pages, 11 × 8.5 × 0.68 inPublished:May 8, 2011Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199798265

ISBN - 13:9780199798261

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Table of Contents

ContributorsPart I Introduction to Basic NeuroscienceSection Editor: Eric J. NestlerEric J. Nestler: Introduction1. John L.R. Rubenstein and Stewart A. Anderson: Overview of brain development2. Ariel Y. Deutch and Robert H. Roth: Neurochemical systems in the central nervous system3. Evelyn K. Lambe and George K. Aghajanian: Using basic electrophysiology to understand the neurobiology of mental illness4. Jean-Antoine Girault and Paul Greengard: Principles of signal transduction5. Eric J. Nestler and Steven E. Hyman: Mechanisms of neural plasticity6. Steven E. Hyman and Eric J. Nestler: Principles of molecular biology7. Lisa M. Monteggia, William A. Carlezon Jr, and Ralph J. DiLeone: Functional genomics and models of mental illness8. Bryan E. McGill and Huda Y. Zoghbi: Epigenetics of psychiatric diseasesPart II Methods of Clinical Neurobiological ResearchSection Editor: Carol A. TammingaCarol A. Tamminga: Introduction9. Kathleen R. Merikangas and Amanda Kalaydjian: Contributions of epidemiology to the neurobiology of mental illness10. Joel Gelernter and Jaakko Lappalainen: Basic methods for clinical molecular genetics of psychiatric illness11. Michael F. Green, Junghee Lee, and Robert S. Kern: Neurocognitive assessment for psychiatric disorders12. Cameron S. Carter, John G. Kerns, and Jonathan D. Cohen: Cognitive neuroscience: Bridging thinking and feeling to the brain, and its implications for psychiatry13. Hanzhang Lu and Yihong Yang: Neuroimaging methods using nuclear magnetic resonance14. Jong-Hoon Kim, Diana Martinez, Mark Slifstein, and Anissa Abi-Dargham: Molecular brain imaging research in mental illness15. Monica Beneyto, Etienne Sibille, and David A. Lewis: Human postmortem brain research in mental illness syndromes16. John M. Petitto, Dean G. Cruess, Martin J. Repetto, David R. Gettes, Tami Benton, and Dwight L. Evans: Neuroimmunology17. Gary D. Tollefson: Drug discovery and development methods for mental illnessPart III PsychosesSection Editor: Jeffrey LiebermanJeffrey Liberman: Introduction18. Michael B. First: Diagnosis of schizophrenia19. Xiangning Chen, Brien Riley and Kenneth S. Kendler: Genetics of schizophrenia20. David A. Lewis and David W. Volk: Neurobiological theories of schizophrenia21. Andrew J. Dwork, John F. Smiley, Tiziano Calibazzi, Matthew J. Hoptman: Postmortem and nn vivo structural pathology in schizophrenia22. Aysenil Belger and Deanna M. Barch: Cognitive neuroscience and neuroimaging in schizophrenia23. Anissa Abi-Dargham: The neurochemistry of schizophrenia: A focus on dopamine and glutamate24. Carol A. Tamminga: Principles of pharmacotherapy of schizophreniaPart IV Mood DisordersSection Editor: Charles B. NemeroffCharles B. Nemeroff: Introduction25. S. Nassir Ghaemi, and Frederick K. Goodwin: Diagnostic classification of mood disorders: historical context and implications for neurobiology26. Falk W. Lohoff and Wade H. Berrettini: Genetics of mood disorders27. Inge Sillaber, Florian Holsboer, and Carsten T. Wotjak: Animal models of mood disorders28. Lisa A. Catapano, Guang Chen, Jing Du, Carlos A. Zarate, Jr., and Husseini K. Manji: Cellular plasticity cascades: Genes to behavior pathways in the pathophysiology and treatment of bipolar disorder29. Ronald S. Duman: Neurochemical theories of depression: preclinial studies30. Boadie Dunlop: The neurochemistry of depressive disorders: Clinical studies31. Wayne C. Drevets: Neuroimaging studies of mood disorders32. Robert M. Berman, Jonathan Sporn, Joseph K. Belanoff, Dennis S. Charney, and Alan Schatzberg: Principles of the pharmacology of depression33. Victoria Arango and J. John Mann: Abnormalities of brain structure and function in mood disorders34. Olivier Berton and Eric J. Nestler: Novel targets for antidepressant treatments35. David R. Rubinow, Peter J. Schmidt, Samantha Meltzer-Brody, and Veronica Harsh: The neurobiology of menstrual-cycle related mood disorders36. Tami D. Benton, Paul Crits-Christoph, Benoit Dube, and Dwight L. Evans: Depression and medical illnessPart V Anxiety DisordersSection Editor: Antonia NewAntonia New: Introduction37. Murray B. Stein and O. Joseph Bienvenu: Diagnostic classification of anxiety disorders: DSM-V and beyond38. Steven P. Hamilton and Abby J. Fyer: The molecular genetics of anxiety disorders39. Gregory M. Sullivan, Jacek Debiec, David E. A. Bush, David M. Lyons, and Joseph E. LeDoux: The neurobiology of fear and anxiety: Contributions of animal models to current understanding40. Bruce S. McEwen: Stress-induced structural and functional plasticity in the brain: protection, damage and brain-body communication41. Amir Garakani, James W. Murrough, Dennis S. Charney, and Douglas Bremner: The neurobiology of anxiety disorders42. Susan E. Swedo and Paul Grant: The neurobiology and treatment of obsessive compulsive disorder43. Justine M. Kent and Scott L. Rauch: Neuroimaging studies of anxiety disorders44. Sanjay J. Mathew, Ellen J. Hoffman, and Dennis S. Charney: Pharmacotherapy of anxiety disorders45. Eliot L. Gardner and Roy A. Wise: Animal models of addictionPart VI Substance Abuse DisordersSection Editor: Steven E. HymanSteven E. Hyman: Introduction46. Eric J. Nestler: Cellular and molecular mechanisms of drug addiction47. Kathleen R. Merikangas and Kevin P. Conway: Genetic epidemiology of substance use disorders48. Barry M. Lester and Barry E. Kosofsky: Effects of drugs of abuse on brain development49. Joanna S. Fowler and Nora D. Volkow: PET and SPECT imaging in substance abuse research50. P. Read Montague and Pearl H. Chiu: Brain reward and fMRI51. Charles P. O'Brien and Charles Dackis: Principles of the pharmacotherapy of addictive disordersPart VII DementiaSection Editor: Mary SanoMary Sano: Introduction52. John Hardy: The genetics and pathogenesis of Alzheimer's disease and related dementias53. Steven Daniel I. Kaufer and Steven T. DeKosky: Diagnostic classifications: Relationship to the neurobiology of dementia54. Gregory A. Elder: Transgenic models of dementias55. Gary L. Wenk: Functional neuroanatomy of learning and memory56. Joanne Berger-Sweeney, Laura R. Schaevitz, and Karyn Frick: Neurochemical systems involved in learning and memory57. Effie M. Mitsis, Maciek Bobinski, Miroslaw Brys, Lidia Glodzik-Sobanska, Susan De Santi, Yi Li, Byeong-Che Kim, Lisa Mosconi, and Mony J. De Leon: Neuropathological and neuroimaging studies of the hippocampus in normal aging and in Alzheimer's disease58. Daniel P. Perl: Abnormalities in brain structure on postmortem analysis of dementia59. Monte S. Buchsbaum, Adam Brickman, Jing Zhang, and Erin A. Hazlett: Functional brain imaging studies in dementia60. Christine Bergmann and Mary Sano: Principles of pharmacotherapy of dementia61. Thomas M. Hyde: Cognitive impairment in demyelinating disease62. David J. Burn, Elaine K. Perry, John T. O'Brien, Neil Archibald, Elizabeta B. Mukaetova-Ladinska, Joaquim Cerejeira, Daniel Collerton, Evelyn Jaros, Robert Perry, Margaret A. Piggott, Chris M. Morris, Andrew McLaren, Clive G. Ballard, and Ian G. McKeith: Dementia with lewy bodies63. Martin Goldstein and C. Warren Olanow: Dementia in Parkinson's disease64. Brendan J. Kelley and Ronald C. Petersen: Mild cognitive impairment65. Steven Z. Chao, Indre Viskontas, and Bruce L. Miller: Frontotemporal dementia66. Nancy Nielsen-Brown and Helena C. Chui: Vascular dementiaPart VIII Psychiatric Disorders of Childhood OnsetSection Editor: Daniel PineDaniel Pine: Introduction67. Antonio Y. Hardan and Allan L. Reiss: The neurobiology of intellectual disabilities68. B.J. Casey and Sarah Durston: Cognitive neuroscience approaches to typical and atypical development69. Kerstin J. Plessen and Bradley S. Peterson: The neurobiology of impulsivity and self-regulatory control in children with attention-deficit/hyperactivity disorder70. Christopher S. Monk and Daniel S. Pine: Childhood anxiety disorders: A cognitive neurobiological perspective71. Jeremy Veenstra-VanderWeele, Randy D. Blakely, and Edwin H. Cook, Jr.: Molecular genetics of childhood and adolescent onset psychiatric disorders72. Ellen Leibenluft: Pediatric bipolar disorder73. Joan Kaufman, Andres Martin, and Hilary Blumberg: Neurobiology of child and adolescent depression74. Jay N. Giedd, Samantha White, and Mark Celano: Structural magnetic resonance imaging of typical pediatric brain development75. Paul J. Lombroso, Michael H. Block, and James F. Leckman: Tourette's syndrome and tic realted disorders in children76. Nitin Gogtay and Judith Rapoport: The neurobiology of childhood psychotic disorders77. Mike Rutter: Developmental perspectives on psychopathology78. Sarah Spence, Paul Grant, Audrey Thurm, and Susan Swedo: Neurobiology of autism and the pervasive developmental disordersPart IX Special Topic AreasSection Editor: Antonia New79. William M. McDonald and Michael S. Okun: Neuropsychiatry: The border between neurology and psychiatry80. Antonia S. New, Joseph Triebwasser and Marianne Goodman: The neurobiology of personality disorders81. R. J. R. Blair: The neurobiology of aggression82. Stuart N. Seidman, Steven P. Roose, Raymond C. Rosen: Sexual dysfunction and pharmacological treatment: Biological interactions83. Thomas R. Insel and James T. Winslow: The neurobiology of social attachment84. Walter Kaye, Michael Strober, and David Jimerson: The neurobiology of eating disorders85. Giulio Tononi and Chiara Cirelli: The neurobiology of sleep86. Margaret Haglund, Paul Nestadt, Nicole S. Cooper, Steven Southwick, and Dennis S. Charney: The neurobiology of resilience87. Daniel R. Wilson: A Brief History of Neural Evolution