Neuroproteomics: Methods and Protocols by Andrew K. OttensNeuroproteomics: Methods and Protocols by Andrew K. Ottens

Neuroproteomics: Methods and Protocols

EditorAndrew K. Ottens, Kevin K.W. Wang

Paperback | July 12, 2012

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With the development of polypeptide ionization processes for mass spectrometry and the rapid processing of large-scale datasets with bioinformatics, researchers now have the tools necessary to propel neuroproteomics research to new levels. In Neuroproteomics: Methods and Protocols, experts in the neurological and analytical sciences present experimental details for applying proteomics to the study of the central nervous system (CNS) and its dysfunction through trauma and disease. Divided into four convenient sections, this collection covers CNS animal models used for neuroproteomics research, methods for separating and analyzing discrete subcomponents of the neuroproteome, large-scale approaches for CNS proteome characterization and quantification, as well as methods that evaluate biofluids and translate neuroproteomic results into clinical platforms. As a volume in the highly successful Methods in Molecular BiologyT series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Neuroproteomics: Methods and Protocols includes the clear "how-to" information needed to critically assess what can be accomplished in the field and how to best perform and evaluate neuroproteomic experiments in one's own research.
Title:Neuroproteomics: Methods and ProtocolsFormat:PaperbackDimensions:334 pages, 10.24 × 7.6 × 0.01 inPublished:July 12, 2012Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617797545

ISBN - 13:9781617797545

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Table of Contents

1. The Methodology of NeuroproteomicsAndrew K. OttensPart I: Disease Models in Neuroproteomics 2. Modeling Cerebral Ischemia in NeuroproteomicsJitendra R. Dave, Anthony J. Williams, Changping Yao, X-C. May Lu, and Frank C. Tortella3. Clinical and Model Research of NeurotraumaAndrás Büki, Erzsebet Kovesdi, Jozsef Pal, and Endre Czeiter4. Neuroproteomic Methods in Spinal Cord InjuryAnshu Chen and Joe E. Springer5. Modeling Substance Abuse for Applications in ProteomicsScott E. Hemby and Nilesh Tannu6. Protein Aggregate Characterization in Models of Neurodegenerative DiseaseAndrew T. N. Tebbenkamp and David R. Borchelt Part II: Sub-Proteome Separations and Neuroproteomic Analysis7. Sub-Proteome Processing: Isolation of Neuromelanin Granules from the Human Brain Florian Tribl8. Proteomic Analysis of Protein Phosphorylation and Ubiquitination in Alzheimer's DiseaseStefani N. Thomas, Diane Cripps, and Austin J. Yang9. Proteomics Identification of Carbonylated and HNE-Bound Brain Proteins in Alzheimer's Disease Rukhsana Sultana and D. Allan Butterfield10. Mass Spectrometric Identification of in vivo Nitrotyrosine Sites in the Human Pituitary Tumor ProteomeXianquan Zhan and Dominic M. Desiderio11. Improved Enrichment and Proteomic Analysis of Brain Proteins with Signaling Function by Heparin ChromatographyKurt Krapfenbauer and Michael Fountoulakis12. Calmodulin Binding Proteome in the BrainZhiqun Zhang, Firas H. Kobeissy, Andrew K. Ottens, Juan A. Martínez, and Kevin K.W. Wang Part III: Neuroproteomic Methodology and Bioinformatics13. Separation of the Neuroproteome by Ion Exchange ChromatographyBrian F. Fuller and Andrew K. Ottens14. iTRAQ-Based Shotgun NeuroproteomicsTong Liu, Jun Hu, and Hong Li15. Methods in Drug Abuse Neuroproteomics: Methamphetamine PsychoproteomeFiras H. Kobaissy, Zhiqun Zhang, Shankar Sadasivan, Mark S. Gold, and Kevin K.W. Wang16. Shotgun Protein Identification and Quantification by Mass Spectrometry In NeuroproteomicsBingwen Lu, Tao Xu, Robin Park, Daniel B. McClatchy, Lujian Liao, and John R. Yates III Part IV: Biofluid Analysis and Clinical Translation17. Identification of Glycoproteins in Human Cerebrospinal FluidHye Jin Hwang, Thomas Quinn, and Jing Zhang18. Mass Spectrometric Analysis of Body Fluids for Biomarker DiscoveryDavid M. Good and Joshua J. Coon19. Traumatic Brain Injury Biomarkers: From Pipeline to Diagnostic Assay DevelopmentMonika W. Oli, Ronald L. Hayes, Gillian Robinson, and Kevin K.W. Wang20. Translation of Neurological Biomarkers to Clinically Relevant PlatformsRonald L. Hayes, Gillian Robinson, Uwe Muller, and Kevin K.W. Wang

Editorial Reviews

From the reviews:"This book provides experimental details about animal models for neuroproteomic research, methods for separating and analyzing discrete subcomponents of the neuroproteome, and CNS proteome characterization and quantification, as well as methods that evaluate biofluids and translate neuroproteomic results into clinical platforms. . The authors intend the book for basic and clinical researchers, and it will be of much interest to basic scientists, clinical scientists, and students interested in applying proteomics to the neurosciences." (Omer Iqbal, Doody's Review Service, March, 2010)