Neuropsychiatric Disorders And Epigenetics

Hardcover | November 11, 2016

byDag YasuiEditorJacob Peedicayil, Dennis R. Grayson

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Neurobehavioral Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neurobehavioral disorders. The volume is organized into 22 chapters representing individual neurological disorders, from Addiction to Stress. The epigenetic aspects of each disorder are addressed by at least two scientists with expertise in that research area. Particular emphasis is placed by each contributing author on potential epigenetic interventions. In an effort to cover a broad range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA, author contributions were selected accordingly. In addition the effects of environmental stimuli on epigenetic states is addressed in some chapters based on relevance to disease induction. Recent discoveries in epigenetic research enabled by advances in genomic technologies, have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders. Clearly neurobehavioral disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with high costs to society. Thus, these collected works will define epigenetics as a key player in neurobehavioral disorders, highlight the full spectrum of epigenetic mechanisms underlying such disorders and introduce the vast range of epigenetic therapies under development. Relates the effects of environmental stimuli on epigenetic states to neurological disease induction Analysis of the epigenetic basis for common neuropsychiatric disorders and how it guides treatment, providing insight and perspective to both clinicians and basic scientists Extensive use of diagrams, illustrations and tables, and graphical abstracts for each subsection permits rapid review

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Neurobehavioral Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neurobehavioral disorders. The volume is organized into 22 chapters representing individual neurological disorders, from Addiction to Stress. The epigenetic aspects of each disorder are addressed by at least two scientists wit...

Dag Yasui is senior project scientist at UC Davis Department of Medical Microbiology and Immunology. His current research program is in the field of chromatin and gene expression regulation in autism spectrum disorders.Jacob Peedicayil has published 46 review papers, 3 book chapters and is engaged in various editorial review boards and...
Format:HardcoverDimensions:436 pages, 9.41 × 7.24 × 0.98 inPublished:November 11, 2016Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128002263

ISBN - 13:9780128002261

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Table of Contents

Preface Dag H. Yasui, Jacob Peedicayil and Dennis R. Grayson

Section I. Neuropsychiatric Disorders and Epigenetics: General Aspects 1. Introduction to Neuropsychiatric Disorders and Epigenetics Dag H. Yasui, Jacob Peedicayil and Dennis R. Grayson

2. Environmental Factors and Epigenetics of Neuropsychiatric Disorders Anke Hoffmann and Dietmar Spengler

3. Epigenetic Biomarkers in Neuropsychiatric Disorders Chin-Chuen Lin, Tiao-Lai Huang

Section II: Epigenetics of Neuropsychiatric Disorders 4. Epigenetics and Cognitive Disorders -Translational Aspects Fabio Coppedè

5. Epigenetics in Pervasive Developmental Disorders - Translational Aspects Takeo Kubota

6. Epigenetic causes of intellectual disability the fragile X syndrome paradigm Elisabetta Tabolacci, Giovanni Neri

7. Epigenetics of Attention-Deficit Hyperactivity Disorder Nader Perroud, Sébastien Weibel, Jean-Michel Aubry, Alexandre Dayer

8. The epigenetics of brain aging and psychiatric disorders Huan Gong, Xiangru Xu

9. Epigenetic therapy may alleviate cognitive deficits in Down syndrome by downregulating overexpressed chromosome 21 gene products Alain D. Dekker, Peter P. De Deyn and Marianne G. Rots

10. Epigenetics and Multiple Sclerosis Lara Kular, Gonçalo Castelo-Branco and Maja Jagodic

11. Epigenetics and Migraine Siew Hua Gan and Munvar Miya Shaik

12. The role of epigenetics in the pathophysiology of epilepsy Sung Min Nam and Kyung-Ok Cho

13. Epigenetic Dysregulation in Brain Tumors and Neurodevelopment Marco M. Hefti and Nadejda Tsankova

14. Epigenetics and Cerebrovascular Diseases Carolina Soriano-Tárraga, Jordi Jiménez-Conde and Jaume Roquer

15. Epigenetics and Eating Disorders Helge Frieling, Vanessa Buchholz

16. Epigenetics in Obesity Brian M. Shewchuk

17. Epigenetics and Drug Addiction-Translational Aspects Jian Feng

18. Epigenetics and Alcohol Use Disorders Sneha Sagarkar and Amul Sakharkar

Section III: Summary and Outlook 19. Summary and Outlook Dag H. Yasui, Jacob Peedicayil and Dennis R. Grayson