Neurotransmitter Release

Paperback | September 30, 1999

EditorHugo Bellen

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Understanding the mechanisms that underlie brain activity and function remains one of the major frontiers of biology. All the processes of how we co-ordinate our movements, sense our surroundings, react to stimuli and learn and retain information rely on complicated networks of neurons thatcommunicate with each other and their targets. This fast and accurate intercellular signalling most occurs at synapses, specialized processes of neurons that release chemical signals, called neurotransmitters. Neurotransmitters: Frontiers in Molecular Biology will provide the reader withextensive background information on neurotransmitter release. It takes a multidisciplinary approach, but does not assume previous knowledge having basic introductions to most topics. Topics however are covered in enough detail to be of interest to experts in the field. Throughout, emphasis is placedon the rationale by which proteins are assigned specific functions rather than just providing facts about function. The first chapter provides an introduction to the basic features and properties of the synapse and is followed by a chapter detailing several important techniques used to elucidatevarious aspects of release. Chapters 3 describes many of the biochemical approaches used to identify proteins involved in neurotransmitter release and then chapters 4 and 5 focus on more specific aspects of synaptic transmission: the proteins that transport neurotransmitters and the role ofphosphlipids in the process. The next five chapters concentrate on approaches to unravel the function of many proteins in vivo by using toxins, giant squid axons, C. elegans, Drosophila, and mice. The final chapter summarizes current knowledge on endocytosis and recycling. Knowledge of themolecular mechanisms underlying neurotransmitter release has expanded tremendously over the last 10 years. Many of the proteins involved have been isolated, but their roles have yet to be determined. These discoveries will be a major challenge and it is therefore the major aim of this book not onlyto provide information but also to generate excitement.

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Understanding the mechanisms that underlie brain activity and function remains one of the major frontiers of biology. All the processes of how we co-ordinate our movements, sense our surroundings, react to stimuli and learn and retain information rely on complicated networks of neurons thatcommunicate with each other and their targets...

Hugo Bellen, Howard Hughes Medical Institute, Houston, Texas.
Format:PaperbackPublished:September 30, 1999Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199637660

ISBN - 13:9780199637669

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Table of Contents

PrefaceList of Contributors1. Kelly: An overview of neurotransmitter release2. Fisher and Oberhauser: Techniques for elucidaing the secretory process; from Ca++ entry to exocytosis3. Hazuka, Foletti and Scheller: 4. Martin: The role of phospholipids in neurosecretion5. Krants, Chaudhry and Edwards: Neurotransmitter transporters6. O'Kane, Schiavo and Sweeney: Toxins that affect neurotransmitter release7. Burns and Augustine: Functional studies of presynaptic proteins at the squid giant synapse8. Nonet: Studying mutants that affect neurotransmitter release in C. elegans9. Pennetta, Wu and Bellen: Dissecting the molecular mechanisms of neurotransmitter release in Drosophila10. Lloyd and Bellen: Genetic analysis of neurotransmitter release in mice and humans11. Zhang and Ramaswami: Synaptic vesicle endocytosis and recyclingIndex