Neutron Protein Crystallography: Hydrogen, Protons, And Hydration In Bio-macromolecules

Hardcover | March 17, 2011

byNobuo Niimura, Alberto Podjarny

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This is one of the first books dedicated to the emerging field of neutron protein crystallography (NPC). The text covers all of the practical aspects of NPC, from the basic background of neutron scattering and diffraction, to the technical details of neutron facilities, growth of high-qualitycrystals, and data analysis. The final chapter is devoted to providing many examples of using NPC to investigate a wide range of different proteins. It demonstrates how NPC can explore hydrogen bonds, protonation and deprotonation of amino acid residues, hydration structures, andhydrogen-to-deuterium exchange ratios. To avoid redundancy with other textbooks on X-ray protein crystallography (XPC), this book assumes a familiarity with the basics of XPC and strives to highlight and explain the differences between XPC and NPC. It is therefore especially useful for X-ray protein crystallographers who are eager tohave a sound, scientific basis for judging if NPC is the right technique for furthering their experimental programs.

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From the Publisher

This is one of the first books dedicated to the emerging field of neutron protein crystallography (NPC). The text covers all of the practical aspects of NPC, from the basic background of neutron scattering and diffraction, to the technical details of neutron facilities, growth of high-qualitycrystals, and data analysis. The final chapt...

Nobuo Niimura took his PhD from the University of Tokyo in 1970. He has since worked in the Physics Division, Tohoku University, and the Japan Atomic Energy Research Institute. He is currenlty Professor at the Frontier Research Center for Applied Atomic Sciences at Ibaraki University. He has received a number of awards for his work: T...
Format:HardcoverDimensions:232 pages, 9.21 × 6.14 × 0.01 inPublished:March 17, 2011Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199578869

ISBN - 13:9780199578863

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Table of Contents

1. The basic principles and experimental configurations of neutron diffraction experiments2. Experimental Procedure for Neutron Protein Crystallography3. Hydrogen, Protons and Hydration in Bio-macromolecules

Editorial Reviews

"A significant contribution, especially with more, and more powerful and accessible neutron sources becoming available around the world." --Joel Bernstein, Dept of Chemistry, Ben Gurion University