New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids by Ana Escribano CuestaNew Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids by Ana Escribano Cuesta

New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids

byAna Escribano Cuesta

Hardcover | August 21, 2013

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Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals.
Title:New Gold-Catalyzed Reactions and Applications for the Synthesis of AlkaloidsFormat:HardcoverDimensions:195 pagesPublished:August 21, 2013Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3319007017

ISBN - 13:9783319007014

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Table of Contents

Introduction.- General Objectives.- Gold(I)-Catalyzed Reactions of 1,6-Enynes with Aldehydes: Cycloaddition versus Metathesis-Type Reactions.- Formation of Cyclobutene Compounds via Gold(I)-Catalyzed Cycloisomerization of 1,n-Enynes.- Approach Toward the Total Synthesis of Lundurines.