New Strategies For N-heterocyclic Carbenes Catalyzed Annulations by Xiangyu ChenNew Strategies For N-heterocyclic Carbenes Catalyzed Annulations by Xiangyu Chen

New Strategies For N-heterocyclic Carbenes Catalyzed Annulations

byXiangyu Chen

Hardcover | December 30, 2016

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This thesis focuses on NHC-catalyzed annulation of nitroalkenes, enals and ?,?-unsaturated carboxylic acids. (1) NHCs were found to be efficient catalysts for the [4+2] annulation of ?-substituted nitroalkenes. The scope of Rauhut-Currier reaction was successfully extended to the most challenging ?-substituted alkenes by this method; (2) Enals were successfully used for [4+2] annulations with azodicarboxylates catalyzed by NHC via ?-addition. Highly enantiopure tetrahydropyridazinones and ?-amino acid derivatives could be easily prepared by subsequent transformations of the resulting dihydropyridazinones. (4) The readily available ?,?-unsaturated carboxylic acids were first successfully employed to generate the ?,?-unsaturated acyl azolium intermediates by using NHC for the enantioselective [3+2] and [3+3] annulations.

Title:New Strategies For N-heterocyclic Carbenes Catalyzed AnnulationsFormat:HardcoverDimensions:123 pagesPublished:December 30, 2016Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9811028982

ISBN - 13:9789811028984

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Table of Contents

Introduction.- NHC-catalyzed Annulations of Nitroalkenes.- NHC-catalyzed Enantioselective Annulations of Enals.- NHC-catalyzed Enantioselective Annulations of ?,?-unsaturated Carboxylic Acids.- Experimental Part.- Research Summary.