Nicotine Safety and Toxicity

Hardcover | August 1, 1998

EditorNeal L. Benowitz

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Nicotine has been developed as a medication to assist smoking cessation, and is being considered as a possible drug for long-term maintenance of non-smoking. It is also undergoing evaluation as a possible treatment for several medical disorders, including ulcerative colitis, Alzheimer'sdisease, Parkinson's disease, Tourette's syndrome, attention deficit disorder, spasticity, and sleep apnea. Understanding its safety and toxicity is essential for drug developers, drug regulators, and clinicians making risk/benefit decisions about long-term nicotine therapy. Research on nicotinetoxicity is also relevant to ongoing research on tobacco and health aimed at understanding the role of nicotine in contributing to tobacco-induced diseases. This book reviews the current scientific understanding of the safety and toxicity of nicotine. The discussion ranges from chemistry, studiesin animals and human experimental research to the results of large clinical trials. Among the topics covered are cardiovascular disease, cancer, reproductive toxicity (including fetal toxicity and Sudden Infant Death Syndrome), behavioral toxicity (including abuse liability and addiction tonicotine medication), and gastrointestinal disease. Finally, contributions explore the risks and benefits of nicotine as a medication. The authors are world-renowned experts on their respective topics. No other book addresses nicotine toxicity in the depth or breadth of this volume. A book on thecutting edge of contemporary public health discourse, Nicotine Safety is an up-to-date and lucid overview of current knowledge on the subject. It will be a necessary addition to the bookshelves of clinicians with an interest in tobacco and health, drug developers and researchers, pharmacologistsand toxicologists, public health researchers and policy-makers.

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Nicotine has been developed as a medication to assist smoking cessation, and is being considered as a possible drug for long-term maintenance of non-smoking. It is also undergoing evaluation as a possible treatment for several medical disorders, including ulcerative colitis, Alzheimer'sdisease, Parkinson's disease, Tourette's syndrome...

Neal L. Benowitz is at University of California, San Francisco.

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Format:HardcoverDimensions:224 pages, 9.29 × 6.3 × 0.98 inPublished:August 1, 1998Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0195114965

ISBN - 13:9780195114966

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Table of Contents

Neal L. Benowitz: 1. Nicotine Pharmacology and AddictionI. Nicotine and Cardiovascular DiseaseNeal L. Benowitz: 2. Cardiovascular Toxicity of Nicotine: Pharmacokinetic and Pharmacodynamic ConsiderationsSteve Gourlay: 3. Cardiovascular Toxicity of Nicotine in AnimalsAke Wennmalm: 4. Cardiovascular Effects of Cigarette Smoke and SnuffStephen I. Rennard, David Daughton, John Windle: 5. Toxicity of Nicotine Replacement in Patients with Coronary Artery DiseaseII. Nicotine and CancerNeal Castagnoli, Jr., Xin Liu, Mark K. Shigenanga, Richard Wardrop, Kay Castagnoli: 6. The Metabolic Fate of (S)-Nicotine and its Pyrrolic Analog b-nicotyrineStephen S. Hecht, Anna Borukhova, Steven G. Carmella: 7. Tobacco-Specific NitrosaminesHildegard M. Schuller: 8. Nicotine and Lung CancerIII. Nicotine and ReproductionT.A. Slotkin: 9. The Impact of Fetal Nicotine Exposure on Nervous System Development and Its Role in Sudden Infant Death Syndrome (SIDS)Gideon Koren, Chrisoula Eliopoulos, Julia Klein: 10. Measuring Fetal Exposure to NicotineCheryl A. Oncken, Hildur Hardardottir, James S. Smeltzer: 11. Human Studies of Nicotine Replacement During PregnancyIV. Behavioral Toxicity of NicotineMaxine L. Stitzer, Harriet de Wit: 12. Abuse Liability of Nicotine

Editorial Reviews

"Benowitz is an internationally recognized expert in the smoking area, with a reputation for excellent research and effective advocacy. Not surprisingly, he has assembled an excellent group of authors to contribute to the book... clearly and consistently written...a succinct starting point forindividuals interested in the topics." -- Edward M. Sellers MD, Canadian Journal of Clinical Pharmacology, Vol 7 , No 1, Spring 2000